用于研究 A 组链球菌侵袭性疾病的人源化纤溶酶原鼠模型。
Humanized Plasminogen Mouse Model to Study Group A Streptococcus Invasive Disease.
机构信息
Cátedras CONACYT-Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, CDMX, Mexico.
Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.
出版信息
Methods Mol Biol. 2020;2136:309-316. doi: 10.1007/978-1-0716-0467-0_24.
This chapter presents the methodology to carry out infection of humanized plasminogen mice with Group A Streptococcus (GAS). This model of invasive disease has been widely used within the field to study the virulence of different GAS strains, host-pathogen interactions, the importance of particular virulence factors, and preclinical evaluation of novel treatments and vaccines. The model has shown to be highly reproducible and therefore represents an invaluable tool for GAS research.
本章介绍了用 A 组链球菌（GAS）感染人源化纤溶酶原小鼠的方法。该侵袭性疾病模型已在该领域内广泛用于研究不同 GAS 菌株的毒力、宿主-病原体相互作用、特定毒力因子的重要性，以及新型治疗方法和疫苗的临床前评估。该模型具有高度可重复性，因此是 GAS 研究的宝贵工具。
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