Department of Intensive Care Medicine and Anaesthesia, Southmead Hospital, Bristol, UK.
Anaesthesia. 2020 Sep;75(9):1205-1214. doi: 10.1111/anae.15038. Epub 2020 May 19.
Organ donation after brain death remains the deceased organ donation pathway of choice. In the UK, the current identification and referral rate for potential donation after brain death donors is 99%, the testing rate for determining death using neurological criteria is 86% and the approach to families for donation is 91%. Increasing donation after brain death donation will primarily require a large increase in the current consent rate of 72% to one matching the consent rate of 80-90% achieved in other European countries. Implementing the use of evidence-based donor optimisation bundles may increase the number of organs available for transplantation. Alternatively, the UK will need to look at more challenging ways of increasing the pool of potential donors after brain death. The first would be to delay the withdrawal of life-sustaining treatment in patients with devastating brain injury to allow progression to brain death after the family have given consent to organ donation and with their consent to this delay. Even more challenging would be the consideration of re-introducing intensive care to facilitate organ donation programmes that have been so successful at increasing the number of organ donors elsewhere.
脑死亡后的器官捐赠仍然是已故器官捐赠的首选途径。在英国,目前潜在脑死亡供体的识别和转介率为 99%,使用神经标准确定死亡的检测率为 86%,向家属提出捐赠的比例为 91%。要增加脑死亡后的器官捐赠,主要需要将目前 72%的同意率大幅提高到与其他欧洲国家 80-90%的同意率相匹配。实施基于证据的供体优化方案可能会增加可用于移植的器官数量。或者,英国将需要寻找更具挑战性的方法来增加脑死亡后潜在供体的数量。第一种方法是在患有严重脑损伤的患者中延迟停止维持生命的治疗,以便在获得器官捐赠同意并同意延迟后,患者进展为脑死亡。更具挑战性的是,考虑重新引入重症监护,以促进在其他地方非常成功地增加器官捐献者数量的器官捐献计划。