Giancristoforo Simona, Diociaiuti Andrea, Tchidjou Hyppolite K, Lucchetti Maria Chiara, Carnevale Claudia, Rotunno Roberta, D'Argenio Patrizia, El Hachem Maya
Dermatology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Pediatric Emergency Services Department, University Hospital, Amiens, France.
Dermatol Ther. 2020 Jul;33(4):e13624. doi: 10.1111/dth.13624. Epub 2020 Jun 5.
Anogenital condylomata acuminata are induced by human papillomavirus (HPV) and they rarely manifest in immunocompetent children. Therapeutic options depend on patient's age and general conditions and extension of the lesions. However, management is still a challenge and recurrences are frequent. Cryotherapy, laser, and surgical treatments in children are painful and frequently require general anesthesia. Imiquimod is a topical immune response modifier and constitutes a noninvasive alternative for the treatment of anogenital condylomata acuminata. Here, we report an infant admitted to our hospital with a giant vegetative papillomatous lesion on the perianal region surrounded by small satellites papules. PCR for HPV confirmed the clinical diagnosis of giant condylomata acuminata due to HPV type 6. The child has been successfully treated with topical 5% imiquimod cream without side effects. Although topical imiquimod is not licensed for pediatric age, this report highlights the potential benefits of its use in selected pediatric cases.
肛门生殖器尖锐湿疣由人乳头瘤病毒（HPV）引起，在免疫功能正常的儿童中很少出现。治疗方案取决于患者的年龄、一般状况以及病变范围。然而，管理仍然是一项挑战，且复发频繁。儿童的冷冻疗法、激光疗法和手术治疗很痛苦，且常常需要全身麻醉。咪喹莫特是一种局部免疫反应调节剂，是治疗肛门生殖器尖锐湿疣的一种非侵入性替代方法。在此，我们报告一名婴儿因肛周区域有巨大的赘生性乳头状瘤病变并伴有小的卫星状丘疹而入住我院。HPV的聚合酶链反应（PCR）证实临床诊断为6型HPV所致的巨大尖锐湿疣。该患儿已成功接受局部5%咪喹莫特乳膏治疗，且无副作用。尽管局部用咪喹莫特未获批准用于儿科，但本报告强调了其在特定儿科病例中的潜在益处。
