不饱和硅杂环的合成——分子内硅-赫克反应
Synthesis of Unsaturated Silyl Heterocycles an Intramolecular Silyl-Heck Reaction.
作者信息
Reid William B, McAtee Jesse R, Watson Donald A
机构信息
Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
出版信息
Organometallics. 2019 Oct 14;38(19):3796-3803. doi: 10.1021/acs.organomet.9b00498. Epub 2019 Sep 26.
Abstract
We report the synthesis of unsaturated silacycles an intramolecular silyl-Heck reaction. Using palladium catalysis, silicon electrophiles tethered to alkenes cyclize to form 5- and 6-membered silicon heterocycles. The effects of alkene substitution and tether length on the efficiency and regioselectivity of the cyclizations are described. Finally, through the use of an intramolecular tether, the first examples of disubstituted alkenes in silyl-Heck reactions are reported.
摘要
我们报道了通过分子内硅基-Heck反应合成不饱和硅杂环的方法。利用钯催化，与烯烃相连的硅亲电试剂环化形成5元和6元硅杂环。描述了烯烃取代基和连接链长度对环化反应效率和区域选择性的影响。最后，通过使用分子内连接链，报道了硅基-Heck反应中双取代烯烃的首例。
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