From the Institute of Gastrosciences and Liver.
Department of Clinical Imaging and Interventional Radiology, AGHL, Kolkata, India.
Pancreas. 2020 May/Jun;49(5):663-667. doi: 10.1097/MPA.0000000000001544.
This study was aimed to determine the relationship between static and dynamic intra-abdominal pressure (IAP) with the mortality and outcome of acute pancreatitis.
From July 2017 to December 2018, 150 patients admitted at the Institute of Gastrosciences and Liver and diagnosed as acute pancreatitis were included in the study. Intra-abdominal pressure was measured for the first few days, and mean value of day 1 (static IAP) and highest value on day 2 and day 3 (dynamic IAP) were calculated and categorized into intra-abdominal hypertension and abdominal compartment syndrome.
A statistical relationship was observed between static and dynamic IAP with the severity and mortality of acute pancreatitis. Both static and dynamic IAPs tended to be higher in nonsurvivors (83.33% and 88.88%, respectively) compared with survivors (51.51% and 63.63%, respectively). Higher IAP had more severe disease. However, IAP did not correlate with the evidence of sepsis or serum procalcitonin levels.
Determination of static IAP is an easy, useful, and inexpensive method to determine and predict the mortality of acute pancreatitis. Prevention and/or early detection of intra-abdominal hypertension helps in reducing the mortality in acute pancreatitis.
本研究旨在确定静态和动态腹腔内压（IAP）与急性胰腺炎死亡率和预后的关系。
2017 年 7 月至 2018 年 12 月，我们将在胃肠病学研究所和肝脏研究所就诊并被诊断为急性胰腺炎的 150 名患者纳入研究。在最初几天测量腹腔内压，并计算第 1 天（静态 IAP）和第 2 天及第 3 天的最高值（动态 IAP）的平均值，并将其分为腹腔内高压和腹腔间隔室综合征。
我们观察到静态和动态 IAP 与急性胰腺炎的严重程度和死亡率之间存在统计学关系。与幸存者（分别为 51.51%和 63.63%）相比，非幸存者的静态（83.33%）和动态 IAP（88.88%）均较高。较高的 IAP 意味着疾病更严重。然而，IAP 与脓毒症的证据或血清降钙素原水平无关。
确定静态 IAP 是一种简单、有用且廉价的方法，可用于确定和预测急性胰腺炎的死亡率。预防和/或早期发现腹腔内高压有助于降低急性胰腺炎的死亡率。
