Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, People's Republic of China.
Department of Obstetrics and Gynecology, The affiliated hospital of Southwest Medical University, Luzhou, People's Republic of China.
Int J Gynaecol Obstet. 2020 Aug;150(2):163-168. doi: 10.1002/ijgo.13228. Epub 2020 Jun 17.
To compare outcomes and prognosis among women with type I endometrial cancer undergoing hysterectomy and bilateral salpingo-oophorectomy (H-BSO) with or without systematic pelvic lymphadenectomy (PLD) or para-aortic lymphadenectomy (PALD).
Retrospective review of women postoperatively diagnosed with type I endometrial cancer who underwent H-BSO at a university hospital in Chengdu, China (January 2010 to June 2012). Women were divided into no lymphadenectomy (PLD-/PALD-), systematic pelvic lymphadenectomy (PLD+/PALD-), or combined pelvic and para-aortic lymphadenectomy (PLD+/PALD+) groups. Follow-up was by telephone. Postoperative outcomes and prognosis were compared and risk factors were analyzed.
In total, 333 women met the inclusion criteria: 121 underwent PLD+/PALD-, 166 underwent PLD+/PALD+, and 46 underwent PLD-/PALD-. There were no differences in pre-operative characteristics among the groups (all P>0.05). The PLD+/PALD+ group had a higher laparotomy rate (P=0.001), the PLD-/PALD- group had shorter operation time (P=0.001) and lower blood loss (P<0.001). There were no differences between the PLD+/PALD- and PLD+/PALD+ groups. Overall, 291 women had sufficient follow-up data; there was no difference in overall survival, and PALD was not a predictor of survival.
Postoperative outcomes were similar among all surgical groups; a survival benefit of PALD was not demonstrated.
比较行子宫切除术和双侧输卵管卵巢切除术（H-BSO）加或不加系统盆腔淋巴结切除术（PLD）或腹主动脉旁淋巴结切除术（PALD）的 I 型子宫内膜癌女性患者的结局和预后。
回顾性分析在中国成都某大学医院接受 H-BSO 的术后诊断为 I 型子宫内膜癌的女性患者（2010 年 1 月至 2012 年 6 月）。将患者分为无淋巴结切除术（PLD-/PALD-）、系统盆腔淋巴结切除术（PLD+/PALD+）或联合盆腔和腹主动脉旁淋巴结切除术（PLD+/PALD+）组。通过电话进行随访。比较术后结局和预后，并分析危险因素。
共 333 名女性符合纳入标准：121 名患者行 PLD+/PALD-，166 名患者行 PLD+/PALD+，46 名患者行 PLD-/PALD-。各组患者术前特征无差异（均 P>0.05）。PLD+/PALD+组的剖腹手术率更高（P=0.001），PLD-/PALD-组的手术时间更短（P=0.001），出血量更少（P<0.001）。PLD+/PALD-和 PLD+/PALD+组之间无差异。总体而言，291 名患者有足够的随访数据；各组总生存率无差异，PALD 不是生存的预测因素。
所有手术组的术后结局相似；PALD 未显示出生存获益。
