Vicario A, Cerezo G H
Unidad Corazón-Cerebro, Servicio de Prevención Cardiovascular, ICBA-Instituto Cardiovascular, Buenos Aires, Argentina.
Unidad Corazón-Cerebro, Servicio de Prevención Cardiovascular, ICBA-Instituto Cardiovascular, Buenos Aires, Argentina.
Hipertens Riesgo Vasc. 2020 Jul-Sep;37(3):125-132. doi: 10.1016/j.hipert.2020.04.003. Epub 2020 May 17.
Arterial hypertension is considered the main modifiable vascular risk factor that causes silent damage to brain vessels. This vascular brain injury could be the common nucleus that justifies the cognitive (cognitive impairment, dementia and Alzheimer's disease) and behavioural symptoms (late-life depression) of target organ damage mediated-hypertension. Incomplete knowledge about the complex pathophysiology that links hypertension with cognitive-behavioural changes is overlooking brain involvement and underestimating cardio and cerebrovascular risk. The confluence of cognitive impairment, depression and arterial hypertension in elderly adults, warns of the need for a comprehensive evaluation to plan treatment, improve prognosis and contribute to reducing the risk of dementia and its incidence.
动脉高血压被认为是导致脑血管隐匿性损伤的主要可改变血管危险因素。这种脑血管损伤可能是一个共同的核心,它解释了高血压介导的靶器官损伤所导致的认知(认知障碍、痴呆和阿尔茨海默病)和行为症状(老年期抑郁症)。关于将高血压与认知行为变化联系起来的复杂病理生理学的认识不足,忽视了大脑的参与,低估了心血管和脑血管风险。老年人中认知障碍、抑郁症和动脉高血压的并存,警示需要进行全面评估,以规划治疗、改善预后并有助于降低痴呆风险及其发病率。