Wallis C, Ballo R, Wallis G, Beighton P, Goldblatt J
Department of Human Genetics, Medical School, University of Cape Town, South Africa.
Genomics. 1988 Nov;3(4):299-301. doi: 10.1016/0888-7543(88)90119-x.
Molecular linkage analysis was undertaken on a large Mauritian kindred with X-linked mixed deafness, stapes fixation, and perilymphatic gusher (X-LDSF). DNA probe pDP34 (DXYS1) was tightly linked to the disorder, with a lod score of 6.32 at zero recombination. This observation indicates that the gene for this form of deafness maps to the Xq13-q21.1 region and has important implications for carrier screening and antenatal diagnosis.
