Barry Janie, Eichler David, Robitaille Robert, Vendittoli Pascal-André
Maisonneuve-Rosemont Hospital, Montreal University, 5415, Boulevard de l'Assomption, Montreal, Quebec, Canada.
Pract Lab Med. 2020 May 8;21:e00167. doi: 10.1016/j.plabm.2020.e00167. eCollection 2020 Aug.
Metal ion blood concentrations evaluation can be useful in monitoring wear and corrosion of orthopedic implants. Elevated metal ion level may help detecting defective hip arthroplasty implants and serve as an indicator for revision surgery. Our objective was to evaluate the reproducibility of titanium metal ion level measurements by two different laboratories.
Seventy-one whole blood samples were collected from 64 patients with unilateral ceramic-on-ceramic hip arthroplasty. For each patient, two whole blood samples were collected and analyzed in two different laboratories.
For each case, laboratory 1 had significantly higher values than laboratory 2. There was a clinically significant absolute difference between the two laboratories, above the predetermined threshold, for 90% of samples. A mean variation ratio of 410% between the two laboratories was found.
Not all laboratories use the same techniques and calibrations to perform these measurements. Therefore, their results should be interpreted with caution and clinical decision should rely on metal ion trends provided by the same laboratory.
金属离子血液浓度评估有助于监测骨科植入物的磨损和腐蚀情况。金属离子水平升高可能有助于检测有缺陷的髋关节置换植入物，并作为翻修手术的指标。我们的目的是评估两个不同实验室测量钛金属离子水平的可重复性。
从64例单侧陶瓷对陶瓷髋关节置换患者中采集了71份全血样本。对于每位患者，采集两份全血样本并在两个不同实验室进行分析。
对于每个病例，实验室1的值显著高于实验室2。在90%的样本中，两个实验室之间存在高于预定阈值的具有临床意义的绝对差异。发现两个实验室之间的平均变异率为410%。
并非所有实验室都使用相同的技术和校准方法来进行这些测量。因此，对其结果的解读应谨慎，临床决策应依赖于同一实验室提供的金属离子趋势。
