Fraix Aurore, Parisi Cristina, Failla Mariacristina, Chegaev Konstantin, Spyrakis Francesca, Lazzarato Loretta, Fruttero Roberta, Gasco Alberto, Sortino Salvatore
PhotoChemLab, Department of Drug Sciences, University of Catania, 95125 Catania, Italy.
Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy.
Chem Commun (Camb). 2020 Jun 11;56(47):6332-6335. doi: 10.1039/d0cc02512g.
We report for the first time a NO photodonor (NOPD) operating with the widely used chemotherapeutic agent doxorubicin (DOX) as the light-harvesting antenna. This permits NO uncaging from an N-nitroso appendage upon selective excitation of DOX with highly biocompatible green light, without precluding its typical red emission. This NOPD effectively binds DNA and photodelivers NO nearby, representing an intriguing candidate for potential multimodal therapeutic applications based on the combination of DOX and NO.
我们首次报道了一种一氧化氮光供体（NOPD），它以广泛使用的化疗药物阿霉素（DOX）作为光捕获天线。这使得在使用具有高度生物相容性的绿光对DOX进行选择性激发时，一氧化氮能够从N-亚硝基附属物上解离出来，同时并不影响其典型的红色发射。这种NOPD能有效结合DNA并在附近光释放一氧化氮，是基于DOX和一氧化氮组合的潜在多模态治疗应用的一个有趣候选物。
