Department of Neurology, Mayo Clinic, 4500 Mellish Rd., Jacksonville, FL, 32224, USA.
National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Clin Auton Res. 2020 Aug;30(4):317-323. doi: 10.1007/s10286-020-00698-x. Epub 2020 May 20.
Renaissance England witnessed a series of brief epidemics of a rapid and often fatal illness, the predominant feature of which was a disturbance of the autonomic nervous system. Profuse sweating was both an emblematic and ominous sign of this Sudor Anglicus. Its story is medically fascinating as well as historically noteworthy. Possible sites of pathological involvement include the hypothalamus, serotonergic neurons in the brainstem or spinal cord, autonomic ganglia, peripheral sympathetic nerves, neuroeffector junctions, or eccrine glands. Of candidate etiologic agents, a virus is most likely, given the seasonal variation, geographic clustering, and pattern of spread of the epidemics. Hantaviruses, enteroviruses, influenza, and others provide clinical comparisons, but a definitive match with known viruses has remained elusive.
文艺复兴时期的英国见证了一系列短暂的快速且往往致命的疾病的流行，这些疾病的主要特征是自主神经系统紊乱。大量出汗既是这种英国汗症的标志性也是不祥的迹象。它的故事不仅在医学上引人入胜，而且在历史上也值得注意。可能的病理受累部位包括下丘脑、脑干或脊髓中的 5-羟色胺能神经元、自主神经节、周围交感神经、神经效应器接头或小汗腺。鉴于流行的季节性变化、地理聚集和传播模式，候选病因包括病毒的可能性最大。汉坦病毒、肠病毒、流感病毒和其他病毒提供了临床比较，但与已知病毒的明确匹配仍然难以捉摸。
