股骨柄长度对肿瘤手术中骨水泥型股骨远端假体置换后无菌性松动的影响。
The effects of length of femoral stem on aseptic loosening following cemented distal femoral endoprosthetic replacement in tumour surgery.
机构信息
Department of Bone Tumor, Tianjin Hospital, 406 Jiefang Southern Road, Tianjin, China.
Graduate School, Tianjin Medical University, 22 Qixiangtai Road, Tianjin, China.
出版信息
Int Orthop. 2020 Jul;44(7):1427-1433. doi: 10.1007/s00264-020-04629-3. Epub 2020 May 20.
PURPOSE
Aseptic loosening is a common prosthetic failure mode. The purpose of this study was to identify dose-response relationship between length of femoral stem and aseptic loosening.
METHODS
We collected data of patients who underwent distal femoral prosthetic replacements at our institution from 2001 to 2017. Cox regression and two-piecewise regression model were used to analyze the associations between stem length and aseptic loosening.
RESULTS
Significant association of length of femoral stem with aseptic loosening was observed in multivariate model and a non-linear relationship could be found from the smoothed curve. In two-piecewise model, an inflection point was calculated to be 143 mm. On the left of the inflection point, every 1 mm increase in the length of stem indicated that the risk of aseptic loosening could be reduced by 6%.
CONCLUSION
There was a significant non-linear relationship between the length of femoral stem and aseptic loosening, and the inflection point was 143 mm.
目的
无菌性松动是一种常见的假体失效模式。本研究旨在确定股骨柄长度与无菌性松动之间的剂量-反应关系。
方法
我们收集了 2001 年至 2017 年在我院接受股骨远端假体置换的患者数据。采用 Cox 回归和两段式回归模型分析股骨柄长度与无菌性松动之间的关系。
结果
在多变量模型中观察到股骨柄长度与无菌性松动之间存在显著关联，并且可以从平滑曲线上发现非线性关系。在两段式模型中，计算出拐点为 143mm。在拐点左侧，股骨柄长度每增加 1mm，无菌性松动的风险可降低 6%。
结论
股骨柄长度与无菌性松动之间存在显著的非线性关系，拐点为 143mm。
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