Application of autologous SOX9 airway basal cells in patients with bronchiectasis.

INTRODUCTION

Bronchiectasis is a common condition and a leading cause of respiratory morbidity and mortality. The treatment method for bronchiectasis is mainly symptomatic treatment or surgery; however, this condition is extremely prone to recurrence.

OBJECTIVES

To preliminarily evaluate the safety and efficacy of applying SOX9 autologous airway basal cells (BCs) in patients with bronchiectasis.

METHODS

SOX9 BCs were isolated from microscale tissue of a grade 3-5 bronchus by bronchoscopic brushing and expanded in vitro for approximately 4 weeks. Subsequently, the autologous SOX9 BCs were transplanted into the diseased bronchus to treat patients with bronchiectasis.

RESULTS

The forced expiratory volume in1 second (FEV1)%, forced vital capacity (FVC)%, total lung capacity (TLC)%, residual volume (RV)% and RV/TLC ratio of predicted value in patients with bronchiectasis were improved at 4, 12, 24 and 48 weeks after cell transplantation, although the differences were not statistically significant (P > .05). Chest CT scans showed that the lesions in the pulmonary segment had not progressed at 4, 12 and 24 weeks after transplantation. No patients died during the follow-up. At 4, 12 and 24 weeks after transplantation, routine blood tests, liver function tests, renal function tests and myocardial enzymatic indexes were normal (P > .05).

CONCLUSION

Transplantation of autologous SOX9 BCs has positive effects and is safe for patients with bronchiectasis.