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一期取出植入物并进行初次髋关节置换是否安全?临床与微生物学分析。

Is it safe to do a single-stage implant exit and primary hip replacement? clinical and microbiological profiling.

作者信息

George Rahul, Hariharan T D, Arunshankar A, Elangovan Divyaa, Lal Binesh, Chandy V J, Oommen A T, Poonnoose Pradeep Mathew

机构信息

Department of Orthopaedics, Christian Medical College, Vellore, Tamil Nadu, India.

Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.

出版信息

Indian J Med Microbiol. 2019 Oct-Dec;37(4):531-535. doi: 10.4103/ijmm.IJMM_20_40.

Abstract

BACKGROUND

A single-stage implant revision for failed fixation of proximal femoral fractures is performed only when there is no evidence of infection. Else, a two-staged revision is preferred - where the definitive revision surgery is done a few months after the implant exit. This study aims to audit the safety and incidence of culture positivity in single-stage revisions.

MATERIALS AND METHODS

Forty one of 284 patients that presented over the last 12 years for implant exchange of the hip, had a single stage revision surgery for failed fixation of a fracture of the hip, as there was no obvious evidence of infection at the time of implant exit.

RESULTS

Micro-organisms were grown in 51% of the 41 hips. 76% were gram positive, of which 63% were Coagulase negative staphylococci (CoNS). 50% of CoNS and 75% of S. aureus were resistant to oxacillin, but susceptible to Vancomycin. Of the gram negative organisms, 2 (Enterobacter sp) were resistant to carbapenam, while others were susceptible. Preoperative ESR and CRP, individually, had low specificity - 50% for ESR >30mm at 1 hour and 62% for CRP>10. The combined use of ESR > 30mm and CRP>10 increased the specificity to 90%. 12% of the patients had immediate postoperative complications that required a wash out in theatre. The long term clinical follow up of these patients is limited.

CONCLUSION

This study suggests that implant exit and simultaneous arthroplasty for failed fracture fixation should be done with caution due to the high possibility of infection. It may be prudent to opt for a 2 stage revision.

摘要

背景

仅在无感染迹象时才对股骨近端骨折内固定失败进行单阶段植入物翻修。否则,两阶段翻修更可取——确定性翻修手术在植入物取出后数月进行。本研究旨在审核单阶段翻修的安全性及培养阳性率。

材料与方法

在过去12年因髋关节植入物置换前来就诊的284例患者中,有41例因髋关节骨折内固定失败接受了单阶段翻修手术,因为在植入物取出时无明显感染迹象。

结果

41例髋关节中有51%培养出微生物。76%为革兰氏阳性菌,其中63%为凝固酶阴性葡萄球菌(CoNS)。50%的CoNS和75%的金黄色葡萄球菌对苯唑西林耐药,但对万古霉素敏感。在革兰氏阴性菌中,2株(肠杆菌属)对碳青霉烯耐药,其他菌株敏感。术前单独的血沉(ESR)和C反应蛋白(CRP)特异性较低——ESR>30mm/h时特异性为50%,CRP>10时特异性为62%。ESR>30mm/h和CRP>10联合使用可将特异性提高至90%。12%的患者术后立即出现并发症,需要在手术室进行冲洗。对这些患者的长期临床随访有限。

结论

本研究表明,由于感染可能性高,骨折固定失败时的植入物取出及同期关节成形术应谨慎进行。选择两阶段翻修可能更为谨慎。

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