The potential of memantine and related adamantanes such as amantadine, to reduce the neurotoxic effects of COVID-19, including ARDS and to reduce viral replication through lysosomal effects.
作者信息
Brenner Steven R
机构信息
Departement of Neurology, Saint Louis University, St. Louis, Missouri.
出版信息
J Med Virol. 2020 Nov;92(11):2341-2342. doi: 10.1002/jmv.26030. Epub 2020 Jun 2.
Abstract
摘要
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1
The potential of memantine and related adamantanes such as amantadine, to reduce the neurotoxic effects of COVID-19, including ARDS and to reduce viral replication through lysosomal effects.美金刚及相关金刚烷类药物（如金刚烷胺）减轻新冠病毒疾病神经毒性作用（包括急性呼吸窘迫综合征）以及通过溶酶体效应减少病毒复制的潜力。
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2
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本文引用的文献
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Adamantanes might be protective from COVID-19 in patients with neurological diseases: multiple sclerosis, parkinsonism and cognitive impairment.金刚烷类药物可能对患有神经系统疾病的 COVID-19 患者具有保护作用：多发性硬化症、帕金森病和认知障碍。
Mult Scler Relat Disord. 2020 Jul;42:102163. doi: 10.1016/j.msard.2020.102163. Epub 2020 Apr 30.
2
Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may be harmful in patients with diabetes during COVID-19 pandemic.在新冠疫情期间，血管紧张素转换酶抑制剂和血管紧张素受体阻滞剂可能对糖尿病患者有害。
Diabetes Metab Syndr. 2020 Jul-Aug;14(4):349-350. doi: 10.1016/j.dsx.2020.04.019. Epub 2020 Apr 15.
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The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients.SARS-CoV2 的神经侵袭性可能在 COVID-19 患者的呼吸衰竭中起作用。
J Med Virol. 2020 Jun;92(6):552-555. doi: 10.1002/jmv.25728. Epub 2020 Mar 11.
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Memantine can relieve the neuronal impairment caused by neurotropic virus infection.盐酸美金刚可缓解神经营养型病毒感染导致的神经元损伤。
J Med Virol. 2019 Jun;91(6):935-940. doi: 10.1002/jmv.25396. Epub 2019 Jan 17.
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mBio. 2017 Apr 25;8(2):e00350-17. doi: 10.1128/mBio.00350-17.
6
Overexpression of angiotensin-converting enzyme 2 attenuates tonically active glutamatergic input to the rostral ventrolateral medulla in hypertensive rats.血管紧张素转换酶 2 的过表达可减弱高血压大鼠延髓头端腹外侧区紧张性谷氨酸能传入。
Am J Physiol Heart Circ Physiol. 2014 Jul 15;307(2):H182-90. doi: 10.1152/ajpheart.00518.2013. Epub 2014 May 16.
7
Novel treatment with neuroprotective and antiviral properties against a neuroinvasive human respiratory virus.新型治疗方法具有神经保护和抗病毒特性，可对抗神经侵袭性人呼吸道病毒。
J Virol. 2014 Feb;88(3):1548-63. doi: 10.1128/JVI.02972-13. Epub 2013 Nov 13.
8
Conductance and amantadine binding of a pore formed by a lysine-flanked transmembrane domain of SARS coronavirus envelope protein.严重急性呼吸综合征冠状病毒包膜蛋白赖氨酸侧翼跨膜结构域形成的孔道的电导和金刚烷胺结合
Protein Sci. 2007 Sep;16(9):2065-71. doi: 10.1110/ps.062730007.
9
Evidence for lysosomotropism of memantine in cultured human cells: cellular kinetics and effects of memantine on phospholipid content and composition, membrane fluidity and beta-adrenergic transmission.美金刚在培养的人类细胞中的溶酶体趋向性证据：细胞动力学以及美金刚对磷脂含量与组成、膜流动性和β-肾上腺素能传递的影响。
Pharmacol Toxicol. 1993 Oct;73(4):202-8. doi: 10.1111/j.1600-0773.1993.tb01564.x.
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