Determination of binding affinity of enantiomers to albumin by liquid chromatography.
作者信息
Marle I, Pettersson C, Arvidsson T
机构信息
Department of Analytical Pharmaceutical Chemistry, University of Uppsala, Sweden.
出版信息
J Chromatogr. 1988 Dec 16;456(2):323-36. doi: 10.1016/0021-9673(86)80028-0.
PMID:3243874
Abstract
The principles of the determination of the binding affinity constants of small molecules to albumin by liquid chromatography, using albumin as a mobile phase additive, are outlined. Chromatographic conditions for determinations of constants are presented and applied to enantiomers of tryptophan and omeprazole. The influence of albumin on the retaining properties of LiChrosorb RP-8, Phenyl Hypersil and LiChrosorb Diol was studied.
摘要
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