Musa M N
Department of Psychiatry, Chicago Medical School, IL 60061.
J Clin Pharmacol. 1988 Nov;28(11):1038-9. doi: 10.1002/j.1552-4604.1988.tb03126.x.
A 41-year-old man developed sleep apnea following abrupt cessation of amitriptyline. Cessation of antidepressants may result in excessive release of acetylcholine, which increases REM sleep. This in turn increases disordered breathing time and decreases nocturnal oxygenation. Sleep apnea did not recur when amitriptyline was reinstated and later gradually discontinued.
一名41岁男性在突然停用阿米替林后出现睡眠呼吸暂停。停用抗抑郁药可能导致乙酰胆碱过度释放，从而增加快速眼动睡眠。这进而增加了呼吸紊乱时间并降低了夜间氧合。重新使用阿米替林后睡眠呼吸暂停未再复发，后来逐渐停药也未复发。
