National Institutes of Health, National Human Genome Research Institute, Social Epidemiology Research Unit, 10 Center Drive, Room 7N320, MSC 1644, Bethesda, MD, United States of America.
National Institutes of Health, National Human Genome Research Institute, Social Epidemiology Research Unit, Bethesda, MD, United States of America.
Prev Med. 2020 Sep;138:106133. doi: 10.1016/j.ypmed.2020.106133. Epub 2020 May 18.
Obesity is associated with age-related health conditions and telomere attrition - a marker of cellular aging. Obesity is attributable to adverse modifiable lifestyle factors. Little is known about the mediation effect of lifestyle factors associated with the relationship between obesity and telomere length. Our objective was to examine this association in the US. Pack years smoked, drinking level per day, physical activity (PA) per week and diet based on Healthy Eating Index (HEI) were assessed as mediators associated with the relationship between adiposity measures and leukocyte telomere length (LTL); adiposity measures included body mass index (BMI), % total body fat (TBF) and waist circumference (WC). Separate adjusted linear regressions and mediation analysis were conducted on a total of 4919 respondents aged 20-84 years using cross-sectional 1999-2002 data from the US National Health and Nutrition Examination Survey. Inadequate PA correlated with 1.28% shorter LTL and was a factor accounting for 35% of the relationship between BMI and LTL (β = -0.0128, 95% CI = 0.0259, 0.0004, p = .05). Smoking 30-≥59 pack years correlated with 4% shorter LTL and accounted for 21% of the relationship between %TBF and LTL (β = -0.0386, 95% CI = -0.0742, -0.0030, p = .03). Improvement in diet correlated with 0.11% longer LTL and contributed 25% of the association between %TBF and LTL (β = 0.0011, 95%CI =0.0004, 0.0018, p = .01). Diet correlated with 0.11% longer LTL and correspond to 28% of the relationship between WC and LTL (β = 0.0011, 95%CI = 0.0004, 0.0018, p = .03). Interventions to improve modifiable behaviors may ameliorate cellular aging and aging related health conditions due to obesity among US adults.
肥胖与与年龄相关的健康状况和端粒损耗有关-细胞衰老的标志物。肥胖是由不良的可改变的生活方式因素引起的。关于与肥胖和端粒长度相关的生活方式因素的中介作用知之甚少。我们的目的是在美国研究这种关联。吸烟年数、每天饮酒量、每周体育活动（PA）和基于健康饮食指数（HEI）的饮食被评估为与肥胖指标和白细胞端粒长度（LTL）之间关系相关的中介因素；肥胖指标包括体重指数（BMI）、总身体脂肪（TBF）%和腰围（WC）。共对来自美国国家健康和营养检查调查的 1999-2002 年横断面数据的 4919 名 20-84 岁的受访者进行了单独的调整线性回归和中介分析。不充分的 PA 与 LTL 缩短 1.28%相关，是 BMI 与 LTL 之间关系的 35%的解释因素（β=-0.0128，95%CI=0.0259，0.0004，p=0.05）。吸烟 30-≥59 包年与 LTL 缩短 4%相关，是 TBF%与 LTL 之间关系的 21%的解释因素（β=-0.0386，95%CI=-0.0742，-0.0030，p=0.03）。饮食改善与 LTL 延长 0.11%相关，是 TBF%与 LTL 之间关联的 25%的解释因素（β=0.0011，95%CI=0.0004，0.0018，p=0.01）。饮食与 LTL 延长 0.11%相关，对应 WC 与 LTL 之间关系的 28%（β=0.0011，95%CI=0.0004，0.0018，p=0.03）。在美国成年人中，改善可改变行为的干预措施可能会减轻肥胖引起的细胞衰老和与衰老相关的健康状况。
