Tamai H, Wakamiya E, Mino M, Iwakoshi M
Department of Pediatrics, Osaka Medical College, Japan.
J Nutr Sci Vitaminol (Tokyo). 1988 Dec;34(6):627-31. doi: 10.3177/jnsv.34.627.
Red blood cell (RBC) alpha-tocopherol and fatty acid levels in children undergoing long-term antiepileptic therapy were examined. Antiepileptic drugs included diphenylhydantoin (PHT), valproic acid (VPA), phenobarbital (PB), and carbamazepine (CBZ). RBC alpha-tocopherol levels were low in patients receiving multi-drug combination therapy, as compared with children receiving no treatment (controls), but plasma alpha-tocopherol levels were the same in both groups. With respect to fatty acid composition in RBCs, docosahexaenoic acid (DHA) level was decreased in children receiving antiepileptic therapy, while no changes were documented in the other fatty acids.
对接受长期抗癫痫治疗的儿童的红细胞（RBC）α-生育酚和脂肪酸水平进行了检测。抗癫痫药物包括苯妥英（PHT）、丙戊酸（VPA）、苯巴比妥（PB）和卡马西平（CBZ）。与未接受治疗的儿童（对照组）相比，接受多药联合治疗的患者红细胞α-生育酚水平较低，但两组的血浆α-生育酚水平相同。关于红细胞中的脂肪酸组成，接受抗癫痫治疗的儿童中二十二碳六烯酸（DHA）水平降低，而其他脂肪酸未发现变化。
