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肾上腺功能不全：免疫检查点抑制剂和免疫相关不良事件管理。

Adrenal Insufficiency: Immune Checkpoint Inhibitors and Immune-Related Adverse Event Management.

机构信息

Loyola University Chicago.

Baptist Health Lexington.

出版信息

Clin J Oncol Nurs. 2020 Jun 1;24(3):240-243. doi: 10.1188/20.CJON.240-243.

DOI:10.1188/20.CJON.240-243
PMID:32441673
Abstract

Adrenal insufficiency (AI) is a potential immune-related adverse event (irAE) of immunotherapy (e.g., checkpoint inhibitor). If not identified and treated promptly, AI can be life-threatening. Unlike other irAEs, AI may be irreversible, requiring long-term glucocorticoid and mineralocorticoid replacement. Provider and patient education are essential in the management of immune checkpoint inhibitor-induced AI.

摘要

肾上腺功能不全（AI）是免疫治疗（如检查点抑制剂）的一种潜在免疫相关不良事件（irAE）。如果不能及时识别和治疗，AI 可能会危及生命。与其他 irAE 不同，AI 可能是不可逆的，需要长期使用糖皮质激素和盐皮质激素替代治疗。在免疫检查点抑制剂引起的 AI 管理中，提供者和患者教育至关重要。

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