Institute of Biochemistry and Molecular Medicine, National Center of Competence in Research NCCR TransCure, University of Bern, Bern, Switzerland.
Department of Chemistry and Biochemistry, National Center of Competence in Research NCCR TransCure, University of Bern, Bern, Switzerland.
Cell Calcium. 2020 Jul;89:102215. doi: 10.1016/j.ceca.2020.102215. Epub 2020 May 11.
TPC2-A1-N and TPC2-A1-P, two novel small molecules, differentially activate two-pore channel 2 (TPC2) and mimic the activation of TPC2 with NAADP and PIP, resulting in distinct ion channel selectivities. These two different modes of TPC2 activity have physiological, and possibly pathophysiological, implications as they can modulate vesicle trafficking and lysosomal exocytosis.
TPC2-A1-N 和 TPC2-A1-P 是两种新型小分子，可差异化激活双孔通道 2（TPC2），并模拟 NAADP 和 PIP 对 TPC2 的激活，从而产生不同的离子通道选择性。这两种不同的 TPC2 活性模式具有生理意义，甚至可能具有病理生理学意义，因为它们可以调节囊泡运输和溶酶体胞吐。
