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孕晚期常规超声检查诊断出的泌尿系统异常的结局

Outcomes of urinary tract abnormalities diagnosed by the routine third trimester scan.

作者信息

Bakalis Spyros, Cao Kevin, Graham Radha, Cuckow Peter, Johal Nav, Winyard Paul, Pandya Pranav, Desai Divyesh

机构信息

Department of Obstetrics, Fetal and Maternal Medicine, Guy's and St Thomas NHS Trust, London, UK.

Department of Urology, Great Ormond Street Hospital for Children, London, UK.

出版信息

Eur J Obstet Gynecol Reprod Biol. 2020 Jul;250:150-154. doi: 10.1016/j.ejogrb.2020.05.008. Epub 2020 May 11.

Abstract

OBJECTIVE

The aim of this study is to determine the incidence of congenital abnormalities of the kidneys and urinary tract (CAKUT) detected for the first time in an unselected population undergoing a routine third trimester scan between 30-34 week's gestation.

METHODS

This was a retrospective analysis of 8562 routine third trimester ultrasound scans during which the fetal anatomy was evaluated, and, any structural abnormalities detected, recorded onto a fetal database which was subsequently analysed for CAKUT. All postnatal records of antenatally diagnosed CAKUT were obtained and analysed for diagnosis and management.

RESULTS

There were 26 cases of urological abnormalities detected for the first time in the third trimester. The most frequent abnormality was unilateral renal pelvis dilatation (73%). Postnatal ultrasound confirmed abnormalities in 19 (73%) newborns, with two (8%) resolving antenatally and four (15%) postnatally. The overall incidence of new CAKUT detected by the third trimester scan was 0.22% (19/8562) with a male to female ratio of 1:1.6. Four patients required surgery, two received cystoscopic injection of Deflux with circumcision, one received cystoscopic valve ablation and one patient received a staged hypospadias repair.

CONCLUSION

Routine third trimester scanning is already performed in many countries with proposed benefits primarily directed towards the monitoring of fetal growth and late pregnancy malpresentation. For healthcare systems that still utilize two routine scans, debate is ongoing as to the value of introducing a routine third trimester scan. The ability to detect additional and potentially missed CAKUT is a further benefit, which in isolation is likely of too small an impact to merit implementation. However, the combination of fetal structural assessment, growth velocity monitoring and fetal presentation evaluation presents a strong case for inclusion in an antenatal screening program. The findings of this study highlight the importance of a detailed fetal structural evaluation at each antenatal ultrasound scan.

摘要

目的

本研究旨在确定在妊娠30 - 34周进行常规孕晚期扫描的未经过筛选的人群中首次检测到的先天性肾脏和尿路异常(CAKUT)的发生率。

方法

这是一项对8562例常规孕晚期超声扫描的回顾性分析,在此期间对胎儿解剖结构进行评估,并将检测到的任何结构异常记录到胎儿数据库中,随后对该数据库进行CAKUT分析。获取并分析所有产前诊断为CAKUT的产后记录,以进行诊断和管理。

结果

在孕晚期首次检测到26例泌尿系统异常。最常见的异常是单侧肾盂扩张(73%)。产后超声证实19例(73%)新生儿存在异常,其中2例(8%)在产前病变消失,4例(15%)在产后病变消失。孕晚期扫描检测到的新CAKUT的总体发生率为0.22%(19/8562),男女比例为1:1.6。4例患者需要手术,2例接受了Deflux膀胱镜注射并进行了包皮环切术,1例接受了膀胱镜瓣膜切除术,1例患者接受了分期尿道下裂修复术。

结论

许多国家已经开展了常规孕晚期扫描,其预期益处主要针对监测胎儿生长和晚期妊娠胎位异常。对于仍采用两次常规扫描的医疗保健系统,关于引入常规孕晚期扫描的价值仍在进行辩论。检测额外的以及可能遗漏的CAKUT的能力是另一项益处,仅凭这一点其影响可能太小而不值得实施。然而,胎儿结构评估、生长速度监测和胎儿胎位评估相结合,有力地支持将其纳入产前筛查计划。本研究结果强调了在每次产前超声扫描时进行详细胎儿结构评估的重要性。

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