University Institute of Biochemistry and Biotechnology, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Rawalpindi 46300, Pakistan.
Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at the University of Gothenburg, Wallenberg Laboratory, 413 45 Gothenburg, Sweden.
Int J Mol Sci. 2020 May 18;21(10):3558. doi: 10.3390/ijms21103558.
Chronic liver disease, with viral or non-viral etiology, is endemic in many countries and is a growing burden in Asia. Among the Asian countries, Pakistan has the highest prevalence of chronic liver disease. Despite this, the genetic susceptibility to chronic liver disease in this country has not been investigated. We performed a comprehensive analysis of the most robustly associated common genetic variants influencing chronic liver disease in a cohort of individuals from Pakistan. A total of 587 subjects with chronic liver disease and 68 healthy control individuals were genotyped for the rs7261356, rs641738, rs1260326, rs738409, rs58542926 and rs4841132 variants. The variants distribution between case and control group and their association with chronic liver disease were tested by chi-square and binary logistic analysis, respectively. We report for the first time that variant results in a 50% reduced risk for chronic liver disease; while and variants increase this risk by more than 35% in Pakistani individuals. Our genetic analysis extends the protective role of the variant against chronic liver disease and disease risk conferred by the ; and variants in the Pakistani population.
慢性肝病，具有病毒或非病毒病因，在许多国家流行，在亚洲是一个不断增长的负担。在亚洲国家中，巴基斯坦的慢性肝病患病率最高。尽管如此，这个国家对慢性肝病的遗传易感性尚未得到调查。我们对来自巴基斯坦的个体队列中的影响慢性肝病的最稳健的相关常见遗传变异进行了全面分析。对 587 例慢性肝病患者和 68 例健康对照个体进行了 rs7261356、rs641738、rs1260326、rs738409、rs58542926 和 rs4841132 变异的基因分型。通过卡方检验和二元逻辑分析分别检验病例组和对照组之间的变异分布及其与慢性肝病的相关性。我们首次报道，变异使慢性肝病的风险降低了 50%；而 和 变异使巴基斯坦个体的这种风险增加了 35%以上。我们的遗传分析扩展了 变异对慢性肝病的保护作用，以及 ； 和 变异在巴基斯坦人群中对疾病风险的影响。
