矫正年龄为12至18个月的早产儿肾脏生长与功能评估
Assessment of Renal Growth and Function in Preterm Infants at Corrected Age of 12-18 Month.
作者信息
Reddy Kallem Venkat, Pawale Dinesh, Shah Mehul, Mouli Deepa, Murki Srinivas
机构信息
Department of Pediatrics, Fernandez Hospital, Hyderguda, Telangana, India. Correspondence to: Dr Venkat Reddy Kallem, Fernandez Hospital, Hyderguda, Hyderabad 500 029, Telangana, India.
Department of Pediatrics, Fernandez Hospital, Hyderguda, Telangana, India.
出版信息
Indian Pediatr. 2020 May 15;57(5):411-414.
OBJECTIVE
To assess the kidney growth and function in appropriate for date and small for date (SGA) preterm neonates.
METHODS
Appropriate for date and SGA preterm neonates with gestation <35 weeks, at 12-18 months of corrected age, attending the follow-up outpatient clinic of a Tertiary care level III neonatal unit. Renal function was assessed by measuring the serum creatinine level and estimated Glomerular Filtration Rate (eGFR) was calculated by using modified Schwartz formula. Kidney size was determined by ultrasonography using a 5 MHz sector probe with an accuracy of 1.0 mm.
RESULTS
The mean (SD) serum creatinine and eGFR in the 120 children enrolled were 0.39 (0.16) mg/dL and 109.05 (44.66) mL/min/1.73 m2, respectively. The mean (SD) lengths of right and left kidney were 54.3 (4.9) mm and 55.2 (4.77) mm, respectively. The kidney length, serum creatinine and eGFR were significantly lower in preterm SGA infants as compared to preterm AGA infants.
CONCLUSION
Preterm infants, especially SGA infants, at 12 to 18 months of corrected age have impaired renal growth with small kidney size.
目的
评估适于胎龄和小于胎龄（SGA）的早产新生儿的肾脏生长及功能。
方法
对胎龄<35周、矫正年龄为12至18个月的适于胎龄和SGA早产新生儿，在一家三级护理水平III级新生儿病房的随访门诊进行研究。通过测量血清肌酐水平评估肾功能，并使用改良的施瓦茨公式计算估计肾小球滤过率（eGFR）。使用5 MHz扇形探头通过超声检查确定肾脏大小，精度为1.0 mm。
结果
纳入的120名儿童的平均（标准差）血清肌酐和eGFR分别为0.39（0.16）mg/dL和109.05（44.66）mL/min/1.73 m²。右肾和左肾的平均（标准差）长度分别为54.3（4.9）mm和55.2（4.77）mm。与早产适于胎龄儿相比，早产SGA婴儿的肾脏长度、血清肌酐和eGFR显著更低。
结论
矫正年龄为12至18个月的早产婴儿，尤其是SGA婴儿，存在肾脏生长受损且肾脏体积小的情况。
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