J Pediatr Rehabil Med. 2020;13(2):205-207. doi: 10.3233/PRM-200707.
Botulinum toxin is frequently used as a therapeutic for a variety of non-FDA approved indications in children. This narrative literature review explores three off-label uses of botulinum toxin in pediatric conditions including congenital muscular torticollis, spastic trismus, and neonatal brachial plexus palsy. While more research is needed to establish treatment, dosing and localization guidelines for the use of botulinum toxin in these commonly treated conditions, available evidence is discussed.
肉毒毒素常用于治疗儿童多种未经 FDA 批准的适应症。本叙事文献综述探讨了肉毒毒素在儿科疾病中的三种超适应证用途，包括先天性肌性斜颈、痉挛性牙关紧闭和新生儿臂丛神经麻痹。虽然需要更多的研究来为这些常见治疗疾病中肉毒毒素的使用建立治疗、剂量和定位指南，但讨论了现有证据。
