Shakhlamov V A, Baranov V N, Rukosuev V S, Kapinus L N
Arkh Patol. 1977;39(2):58-64.
Electron-microscopic investigation carried out following the intravenous administration of ferritin revealed an increase in permeability of the myocardium capillary wall in mice in experimental casein amyloidosis. Additionally, a complex electron-microscopic, immunohistochemical and histological investigation of the development of amyloidosis in the myocardium of mice was conducted. It was established that deposits of typical amyloid in the myocardium of mice consisted of two ultrastructural components--granular material and fibrils. It was shown that formation of amyloid with characteristic tinctorial properties was preceded by depositions of specific antigen fibrils of granular ultrastructure.
在静脉注射铁蛋白后进行的电子显微镜研究显示，在实验性酪蛋白淀粉样变性的小鼠中，心肌毛细血管壁的通透性增加。此外，还对小鼠心肌淀粉样变性的发展进行了复杂的电子显微镜、免疫组织化学和组织学研究。结果表明，小鼠心肌中典型淀粉样蛋白沉积物由两种超微结构成分组成——颗粒物质和纤维。研究表明，具有特征性染色特性的淀粉样蛋白形成之前，先有颗粒超微结构的特异性抗原纤维沉积。
