Dental Core Trainee, University Dental Hospital of Manchester, UK.
Speciality Registrar in Oral Medicine, University Dental Hospital of Manchester, UK.
Br Dent J. 2020 May;228(10):757-760. doi: 10.1038/s41415-020-1530-x.
There is a strong association between tobacco use and the development of oral mucosal lesions, often with malignant potential. Nicotine is the primary component of tobacco responsible for addiction. The use of nicotine replacement therapy (NRT) aims to replace nicotine from cigarettes, allowing smoother transition to complete smoking cessation and greatly reducing risks of tobacco-related disease. The role of nicotine as a potential carcinogen is unknown. Use of NRT is associated with development of oral disorders, although it is rarely published. We detail the development of oral hyperkeratotic lesions directly associated with chronic overuse of nicotine replacement products. We also consider the current state of knowledge regarding development of oral lesions associated with other similar products. It is important for dental practitioners to be aware of oral effects associated with recommended nicotine replacement products, especially when offering smoking cessation advice to patients. It is vital that dental practitioners are aware of other potential risk factors for development of potentially malignant oral disorders, in order to make timely referrals of suspected lesions for appropriate investigation and review.
吸烟与口腔黏膜病变的发生有很强的关联性，这些病变往往具有恶性潜能。尼古丁是烟草中导致成瘾的主要成分。尼古丁替代疗法（NRT）的使用旨在替代香烟中的尼古丁，从而更顺利地过渡到完全戒烟，并大大降低与烟草相关的疾病风险。尼古丁作为一种潜在的致癌物质的作用尚不清楚。尽管有关口腔疾病的报道很少，但 NRT 的使用与口腔疾病的发生有关。我们详细描述了与慢性过度使用尼古丁替代产品直接相关的口腔过度角化病变的发展。我们还考虑了与其他类似产品相关的口腔病变发展的现有知识状况。牙医了解与推荐的尼古丁替代产品相关的口腔影响非常重要，特别是在向患者提供戒烟建议时。牙医必须了解其他潜在的恶性口腔疾病发展的危险因素，以便及时转介疑似病变进行适当的检查和复查。
