• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

唐氏综合征患者是否易感染危及生命的 COVID-19？

Are patients with Down syndrome vulnerable to life-threatening COVID-19?

机构信息

Department of Neurology, Dimpna Regional Hospital, AZ St Dimpna, JB Stessenstraat 2, 2440, Geel, Belgium.

Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.

出版信息

Acta Neurol Belg. 2021 Jun;121(3):685-687. doi: 10.1007/s13760-020-01373-8. Epub 2020 May 22.

DOI:10.1007/s13760-020-01373-8
PMID:32444942
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7243430/
Abstract

Patients with Down syndrome are at increased risk of respiratory syncytial virus- and H1N1-related death. Literature on COVID-19 in Down syndrome patients is unavailable thus far. We describe the clinical course of 4 patients with Down syndrome during an outbreak of COVID-19. In all four patients, disease course was severe, warranting hospital care in three patients, with fatal outcome in one patient. Another patient receives supportive care in our institution. Our case series is the first report on probable increased risk of life-threatening disease course of COVID-19 in patients with Down syndrome. Proper surveillance, the adherence of social distancing, and the use of personal protective equipment will be essential in reducing morbidity and mortality in our patients.

摘要

唐氏综合征患者患呼吸道合胞病毒和 H1N1 相关死亡的风险增加。目前尚无关于唐氏综合征患者 COVID-19 的文献。我们描述了 4 名唐氏综合征患者在 COVID-19 爆发期间的临床过程。在所有 4 名患者中，疾病过程均很严重，3 名患者需要住院治疗，其中 1 名患者死亡。另一名患者在我院接受支持性治疗。我们的病例系列是第一份关于唐氏综合征患者 COVID-19 致死风险增加的报告。适当的监测、遵守社会距离和使用个人防护设备对于降低我们患者的发病率和死亡率至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf42/7243430/dd849fb0db3f/13760_2020_1373_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf42/7243430/cf911e359c9f/13760_2020_1373_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf42/7243430/dd849fb0db3f/13760_2020_1373_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf42/7243430/cf911e359c9f/13760_2020_1373_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf42/7243430/dd849fb0db3f/13760_2020_1373_Fig2_HTML.jpg

相似文献

1
Are patients with Down syndrome vulnerable to life-threatening COVID-19?唐氏综合征患者是否易感染危及生命的 COVID-19？
Acta Neurol Belg. 2021 Jun;121(3):685-687. doi: 10.1007/s13760-020-01373-8. Epub 2020 May 22.
2
Down Syndrome patients with COVID-19 pneumonia: A high-risk category for unfavourable outcome.唐氏综合征合并 COVID-19 肺炎患者：预后不良的高危人群。
Int J Infect Dis. 2021 Feb;103:607-610. doi: 10.1016/j.ijid.2020.11.188. Epub 2020 Nov 30.
3
Human and novel coronavirus infections in children: a review.儿童人感染和新型冠状病毒感染：综述。
Paediatr Int Child Health. 2021 Feb;41(1):36-55. doi: 10.1080/20469047.2020.1781356. Epub 2020 Jun 25.
4
Adherence to social distancing and use of personal protective equipment and the risk of SARS-CoV-2 infection in a cohort of patients with multiple sclerosis.多发性硬化症患者队列中，遵守社交距离和使用个人防护设备与 SARS-CoV-2 感染风险的关系。
Mult Scler Relat Disord. 2020 Oct;45:102359. doi: 10.1016/j.msard.2020.102359. Epub 2020 Jul 3.
5
Society of swallowing and dysphagia of Japan: Position statement on dysphagia management during the COVID-19 outbreak.日本吞咽与吞咽困难学会：关于COVID-19疫情期间吞咽困难管理的立场声明。
Auris Nasus Larynx. 2020 Oct;47(5):715-726. doi: 10.1016/j.anl.2020.07.009. Epub 2020 Jul 23.
6
Post-infectious inflammatory syndrome associated with SARS-CoV-2 in a paediatric patient with Down syndrome.儿童唐氏综合征患者感染 SARS-CoV-2 后并发炎症综合征。
BMJ Case Rep. 2021 Apr 15;14(4):e240490. doi: 10.1136/bcr-2020-240490.
7
Evidence of Severe Acute Respiratory Syndrome Coronavirus 2 Replication and Tropism in the Lungs, Airways, and Vascular Endothelium of Patients With Fatal Coronavirus Disease 2019: An Autopsy Case Series.严重急性呼吸综合征冠状病毒 2 在 COVID-19 死亡患者肺部、气道和血管内皮中的复制和嗜性的证据：一项尸检病例系列研究。
J Infect Dis. 2021 Mar 3;223(5):752-764. doi: 10.1093/infdis/jiab039.
8
[Detection and evaluation of SARS-CoV-2 nucleic acid contamination in corona virus disease 19 ward surroundings and the surface of medical staff's protective equipment].[新型冠状病毒肺炎病房环境及医务人员防护用品表面严重急性呼吸综合征冠状病毒2核酸污染的检测与评估]
Beijing Da Xue Xue Bao Yi Xue Ban. 2020 Oct 18;52(5):803-808. doi: 10.19723/j.issn.1671-167X.2020.05.002.
9
COVID-19 respiratory support in the emergency department setting.急诊科的 COVID-19 呼吸支持。
Am J Emerg Med. 2020 Oct;38(10):2160-2168. doi: 10.1016/j.ajem.2020.08.001. Epub 2020 Aug 8.
10
Pathogenesis-directed therapy of 2019 novel coronavirus disease.针对 2019 新型冠状病毒病的发病机制导向治疗。
J Med Virol. 2021 Mar;93(3):1320-1342. doi: 10.1002/jmv.26610. Epub 2020 Nov 10.

引用本文的文献

1
Tailored vs. General COVID-19 prevention for adults with mental disabilities residing in group homes: a randomized controlled effectiveness-implementation trial.针对群居的成年精神残障人士的个体化与一般化 COVID-19 预防措施比较：一项随机对照有效性-实施试验。
BMC Public Health. 2024 Jun 26;24(1):1705. doi: 10.1186/s12889-024-18835-w.
2
COVID-19 in patients with Down syndrome: A systematic review.唐氏综合征患者的 COVID-19：系统评价。
Immun Inflamm Dis. 2024 Mar;12(3):e1219. doi: 10.1002/iid3.1219.
3
Enhancing understanding of SARS-CoV-2 infection among individuals with Down syndrome: An integrative review.

本文引用的文献

1
Comparison of SARS-CoV-2 detection from nasopharyngeal swab samples by the Roche cobas 6800 SARS-CoV-2 test and a laboratory-developed real-time RT-PCR test.罗氏 cobas 6800 SARS-CoV-2 检测与实验室开发的实时 RT-PCR 检测对鼻咽拭子样本中 SARS-CoV-2 的检测比较。
J Med Virol. 2020 Sep;92(9):1695-1698. doi: 10.1002/jmv.25988. Epub 2020 May 22.
2
Respiratory Syncytial Virus-related Death in Children With Down Syndrome: The RSV GOLD Study.呼吸道合胞病毒相关死亡的儿童唐氏综合征：RSV 黄金研究。
Pediatr Infect Dis J. 2020 Aug;39(8):665-670. doi: 10.1097/INF.0000000000002666.
增强唐氏综合征个体对 SARS-CoV-2 感染的认识：综合述评。
Sao Paulo Med J. 2023 Aug 21;142(2):e2023015. doi: 10.1590/1516-3180.2023.0015.R1.230523. eCollection 2023.
4
Risk for Severe Illness and Death among Pediatric Patients with Down Syndrome Hospitalized for COVID-19, Brazil.巴西因 COVID-19 住院的唐氏综合征儿科患者严重疾病和死亡风险。
Emerg Infect Dis. 2023 Jan;29(1):26-35. doi: 10.3201/eid2901.220530.
5
COVID-19 hospitalization with later long COVID in a person with Down syndrome.一名唐氏综合征患者因新冠病毒疾病住院，之后出现了长期新冠症状。
Clin Case Rep. 2022 Oct 7;10(10):e6425. doi: 10.1002/ccr3.6425. eCollection 2022 Oct.
6
'Now that I am connected this isn't social isolation, this is engaging with people': Staying connected during the COVID-19 pandemic.“既然我现在能与人联系，这就不是社交隔离，而是与人交往”：在新冠疫情期间保持联系。
Br J Learn Disabil. 2022 Apr 22. doi: 10.1111/bld.12478.
7
Impact of the COVID-19 pandemic on daily life, mood, and behavior of adults with Down syndrome.COVID-19 大流行对唐氏综合征成年人日常生活、情绪和行为的影响。
Disabil Health J. 2022 Jul;15(3):101278. doi: 10.1016/j.dhjo.2022.101278. Epub 2022 Feb 17.
8
Adapted remote cognitive behavioural therapy for comfort eating with a woman with intellectual disabilities: Case report.为一名智障女性调适性暴食症采用远程认知行为疗法：病例报告
J Eat Disord. 2022 Feb 22;10(1):29. doi: 10.1186/s40337-022-00537-6.
9
Aging with Down Syndrome-Where Are We Now and Where Are We Going?唐氏综合征与衰老——我们现在所处的位置以及未来的方向？
J Clin Med. 2021 Oct 13;10(20):4687. doi: 10.3390/jcm10204687.
10
Understanding inequalities in COVID-19 outcomes following hospital admission for people with intellectual disability compared to the general population: a matched cohort study in the UK.了解与普通人群相比，因 COVID-19 住院的智力残疾患者的结局不平等情况：英国一项匹配队列研究。
BMJ Open. 2021 Oct 4;11(10):e052482. doi: 10.1136/bmjopen-2021-052482.