Centre for THz Research, China Jiliang University, Hangzhou City, Zhejiang Province, China.
Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou City, Zhejiang Province, China.
Curr Pharm Des. 2020;26(38):4829-4846. doi: 10.2174/1381612826666200523173448.
Cocrystallization of specific active pharmaceutical ingredients (APIs) in the solid-state phase is becoming a feasible way to improve their corresponding physicochemical properties and ultimate bioavailability without making and breaking any covalent bonds within them. Many recent reports deal with the characterization and analysis topics of pharmaceutical APIs-based cocrystals. In this mini-review, we will focus on the recent steady-state and time-dependent spectroscopic investigation into the cocrystallization of specific APIs based on both Raman and emerging terahertz spectroscopy in pharmaceutical fields. Distinctive spectral, structural and also kinetic information of pharmaceutical APIs-based cocrystals are obtained and discussed, which would highlight the potential of vibrational spectroscopy as an attractive technique for various drug research and development during cocrystallization of specific APIs.
特定活性药物成分（APIs）在固态中的共结晶正在成为一种可行的方法，可在不打破其内部任何共价键的情况下改善它们相应的物理化学性质和最终生物利用度。许多最近的报告涉及基于药物 API 的共晶的特征描述和分析主题。在这篇迷你综述中，我们将重点介绍基于拉曼和新兴太赫兹光谱学在制药领域对特定 API 共结晶的稳态和时变光谱研究。获得并讨论了基于药物 API 的共晶的独特光谱、结构和动力学信息，这将突出振动光谱作为一种有吸引力的技术在特定 API 共结晶过程中用于各种药物研究和开发的潜力。
