优化所有 COVID-19 患者用药剂量的真实世界证据框架。
A Real-World Evidence Framework for Optimizing Dosing in All Patients With COVID-19.
机构信息
Clinical Pharmacology, Pharma Research & Early Development, Roche Innovation Center, Basel, Switzerland.
Pharmacometrics Consultant, Chapel Hill, North Carolina, USA.
出版信息
Clin Pharmacol Ther. 2020 Nov;108(5):921-923. doi: 10.1002/cpt.1922. Epub 2020 Jun 29.
Potential treatments for coronavirus disease 2019 (COVID-19) are being investigated at unprecedented speed, and successful treatments will rapidly be used in tens or hundreds of thousands of patients. To ensure safe and effective use in all those patents it is essential also to develop, at unprecedented speed, a means to provide frequently updated, optimal dosing information for all patient subgroups. Success will require immediate collaboration between drug developers, academics, and regulators.
正在以空前的速度研究 2019 年冠状病毒病（COVID-19）的潜在治疗方法，成功的治疗方法将迅速在数万或数十万患者中使用。为确保所有患者安全有效地使用，还必须以空前的速度开发一种方法，为所有患者亚组提供经常更新的最佳剂量信息。成功将需要药物开发商、学者和监管机构之间的立即合作。
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