Hamburg Epilepsy Center, Protestant Hospital Alsterdorf, Department of Neurology and Epileptology, Hamburg, Germany.
Universität Hamburg, Department of Mathematics, Hamburg, Germany.
Epilepsy Res. 2020 Aug;164:106367. doi: 10.1016/j.eplepsyres.2020.106367. Epub 2020 May 16.
Stiripentol is an orphan drug successfully used in combination with valproate and clobazam in the treatment of Dravet syndrome. Perampanel has also been added by experts. In this retrospective study, we investigated the influence of stiripentol on perampanel serum levels by using the doses and corresponding perampanel serum levels of 10 patients. The impact of stiripentol on the perampanel serum levels was significant as shown in a linear regression analysis, with perampanel serum levels increasing linearly with the stiripentol doses. We conclude that dose adjustments of stiripentol and perampanel when administered together, should be done carefully to avoid side effects or even severe intoxication. Hence, perampanel serum level monitoring seems advisable.
曲莱（Stiripentol）是一种孤儿药，已成功与丙戊酸钠和氯巴占联合用于治疗德拉维综合征。专家还加入了吡仑帕奈。在这项回顾性研究中，我们使用 10 名患者的剂量和相应的吡仑帕奈血清水平，研究了曲莱对吡仑帕奈血清水平的影响。线性回归分析显示，曲莱对吡仑帕奈血清水平的影响显著，吡仑帕奈血清水平随曲莱剂量呈线性增加。我们得出结论，当联合使用曲莱和吡仑帕奈时，应谨慎调整剂量，以避免副作用甚至严重中毒。因此，监测吡仑帕奈的血清水平似乎是明智的。
