人多能干细胞源性心脏基质细胞及其在再生医学中的应用。
Human pluripotent stem cell-derived cardiac stromal cells and their applications in regenerative medicine.
机构信息
Department of Chemical and Biological Engineering, University of Wisconsin - Madison, Madison, WI, USA.
Department of Chemical and Biological Engineering, University of Wisconsin - Madison, Madison, WI, USA.
出版信息
Stem Cell Res. 2020 May;45:101831. doi: 10.1016/j.scr.2020.101831. Epub 2020 Apr 27.
Coronary heart disease is one of the leading causes of death in the United States. Recent advances in stem cell biology have led to the development and engineering of human pluripotent stem cell (hPSC)-derived cardiac cells and tissues for application in cellular therapy and cardiotoxicity studies. Initial studies in this area have largely focused on improving differentiation efficiency and maturation states of cardiomyocytes. However, other cell types in the heart, including endothelial and stromal cells, play crucial roles in cardiac development, injury response, and cardiomyocyte function. This review discusses recent advances in differentiation of hPSCs to cardiac stromal cells, identification and classification of cardiac stromal cell types, and application of hPSC-derived cardiac stromal cells and tissues containing these cells in regenerative and drug development applications.
冠心病是美国的主要死因之一。近年来，干细胞生物学的进展使得人们能够开发和设计源自人类多能干细胞（hPSC）的心肌细胞和组织，用于细胞治疗和心脏毒性研究。该领域的初步研究主要集中在提高心肌细胞的分化效率和成熟状态上。然而，心脏中的其他细胞类型，包括内皮细胞和基质细胞，在心脏发育、损伤反应和心肌细胞功能中起着至关重要的作用。本文综述了 hPSC 向心脏基质细胞分化的最新进展，讨论了心脏基质细胞类型的鉴定和分类，以及包含这些细胞的 hPSC 衍生的心脏基质细胞和组织在再生和药物开发应用中的应用。
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