Calculations and application of mean residence times for drugs which demonstrate one-compartment distribution and Michaelis-Menten elimination.

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作者信息

Cook J A, Gwilt P R

机构信息

College of Pharmacy, University of Michigan, Ann Arbor 48109-1065.

出版信息

Pharm Res. 1988 Mar;5(3):196. doi: 10.1023/a:1015977209836.

DOI:10.1023/a:1015977209836

PMID:3244635

Abstract

摘要

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Input-output analysis for total input rate and total traced mass of body cholesterol in man.人体胆固醇总输入率和总追踪质量的投入产出分析。

Circ Res. 1969 Aug;25(2):191-9. doi: 10.1161/01.res.25.2.191.

Properties of the Michaelis-Menten equation and its integrated form which are useful in pharmacokinetics.米氏方程及其积分形式在药代动力学中有用的性质。

J Pharmacokinet Biopharm. 1973 Apr;1(2):103-21. doi: 10.1007/BF01059625.

The mean residence time of drugs in the systemic circulation.

J Pharm Sci. 1985 Jul;74(7):791-2. doi: 10.1002/jps.2600740723.

The determination of mean residence time using statistical moments: it is correct.

J Pharmacokinet Biopharm. 1985 Oct;13(5):549-54. doi: 10.1007/BF01059336.

Definition of mean residence times in pharmacokinetics.

Biopharm Drug Dispos. 1987 Jan-Feb;8(1):87-97. doi: 10.1002/bdd.2510080110.

Application of moment analysis to nonlinear drug disposition described by the Michaelis-Menten equation.矩量分析在由米氏方程描述的非线性药物处置中的应用。

Pharm Res. 1987 Feb;4(1):59-61. doi: 10.1023/a:1016486012446.

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