Fanelli R J, Walovitch R C, Jasinski D R, London E D
Neuropharmacology Laboratory, National Institute on Drug Abuse, Baltimore, MD 21224.
Pharmacol Biochem Behav. 1988 Oct;31(2):481-5. doi: 10.1016/0091-3057(88)90377-2.
The autoradiographic, 2-deoxy-D-[1-14C]glucose ([14C]DG) method was used to map the effects of intravenous (IV) naloxone (1.0, 10.0, and 20.0 mg/kg) on local cerebral glucose utilization (LCGU), an index of local brain function. Naloxone injected 5 min before [14C]DG did not alter LCGU in any of the fifty-six brain regions examined. Our findings suggest that acute naloxone at these doses does not significantly affect cerebral metabolism.
