Department of Spinal Surgery, General Hospital of Ningxia Medical University, Ningxia Medical University, 804 Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People's Republic of China.
First Affiliated Hospital of Nanchang University, No.17 Yong Wai Zheng Street Donghu District, Nanchang, 330006, Jiangxi, People's Republic of China.
Eur Spine J. 2020 Aug;29(8):1813-1822. doi: 10.1007/s00586-020-06466-9. Epub 2020 May 23.
The goal of this study was to review relevant randomized controlled trials in order to determine the clinical efficacy of golimumab in the treatment of ankylosing spondylitis (AS).
Using appropriate keywords, we identified relevant studies using PubMed, Cochrane and Embase. Key pertinent sources in the literature were also reviewed, and all articles published through November 2019 were considered for inclusion. For each study, we assessed odds ratios, mean difference and 95% confidence interval to assess and synthesize outcomes.
We included nine studies with 6363 patients. Compared with placebo, golimumab would significant decreased the value of BASFI, BASMI, BASDAI, total back pain, JSEQ; increased the value of SF-36 PCS and SF-36 MCS; increased the incidence of BASDAI50, ASAS20, ASAS40 and ASAS partial remission. Compared with golimumab 50 mg, golimumab 100 mg would significantly decreased the value of BASFI and total back pain; increased the value of SF-36 PCS and SF-36 MCS; but also increased the incidence of SAE.
Golimumab had a definite effect in the treatment of AS. The higher dose would obtain better efficacy but lead to the incidence of SAE.
本研究旨在回顾相关的随机对照试验，以确定戈利木单抗治疗强直性脊柱炎（AS）的临床疗效。
使用适当的关键词，我们通过 PubMed、Cochrane 和 Embase 确定了相关研究。还回顾了文献中的关键来源，并考虑了截至 2019 年 11 月发表的所有文章。对于每项研究，我们评估了比值比、均数差和 95%置信区间，以评估和综合结果。
我们纳入了 9 项研究，共 6363 名患者。与安慰剂相比，戈利木单抗可显著降低 BASFI、BASMI、BASDAI、总背痛、JSEQ 的评分；增加 SF-36 PCS 和 SF-36 MCS 的评分；增加 BASDAI50、ASAS20、ASAS40 和 ASAS 部分缓解的发生率。与戈利木单抗 50mg 相比，戈利木单抗 100mg 可显著降低 BASFI 和总背痛评分；增加 SF-36 PCS 和 SF-36 MCS 的评分；但也增加了 SAE 的发生率。
戈利木单抗治疗 AS 具有明确的疗效。高剂量可获得更好的疗效，但会导致 SAE 的发生率增加。
