Chen Y, Wang A H, Yi B, Ding K Q, Wang H B, Wang J M, Shi H B, Wang S J, Xu G Z
Department of Communicable Disease Control and Prevention, Department of Occupational Health and Environmental Health, Ningbo Municipal Centre for Disease Control and Prevention, Ningbo 315010, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2020 May 10;41(5):667-671. doi: 10.3760/cma.j.cn112338-20200304-00251.
To estimate the infection rate of close contacts of COVID-19 cases, and to evaluate the risk of COVID-19 under different exposure conditions. A prospective study was used to conduct continuous quarantine medical observations of close contacts of people infected with COVID-19, collect epidemiological, clinical manifestations, and laboratory test data to estimate the infection rate of close contacts under different exposures. The epidemiological curve of COVID-19 in Ningbo showed persistent human-to-human characteristics. A total of 2 147 close contacts were tracked and investigated. The total infection rate was 6.15%. The infection rates of confirmed cases and positive contacts were 6.30% and 4.11%, respectively. The difference was not statistically significant (>0.05). Among close contacts of different relationships, friends/pilgrims (22.31%), family members (18.01%), and relatives (4.73%) have a higher infection rate, and close contacts of medical staff were not infected. Differences in infection rates among the close contacts were statistically significant (<0.005). Living with the case (13.26%), taking the same transportation (11.91%), and dining together (7.18%) are high risk factors for infection. Cross-infection in the hospital should not be ignored (1.94%). The median of incubation period is 5 days. The infection rate of close contacts of COVID-19 cases is high, and isolation medical observation measures should be implemented in strict accordance with the close contact management plan.
为估算新型冠状病毒肺炎(COVID-19)病例密切接触者的感染率,并评估不同暴露条件下COVID-19的感染风险。采用前瞻性研究对COVID-19感染者的密切接触者进行连续隔离医学观察,收集流行病学、临床表现及实验室检测数据,以估算不同暴露情况下密切接触者的感染率。宁波市COVID-19的流行病学曲线呈现持续人传人的特征。共追踪调查了2147名密切接触者。总感染率为6.15%。确诊病例和阳性接触者的感染率分别为6.30%和4.11%。差异无统计学意义(>0.05)。在不同关系的密切接触者中,朋友/同行者(22.31%)、家庭成员(18.01%)和亲属(4.73%)的感染率较高,医护人员的密切接触者未出现感染。密切接触者之间的感染率差异有统计学意义(<0.005)。与病例同住(13.26%)、乘坐同一交通工具(11.91%)和共同就餐(7.18%)是感染的高风险因素。医院内的交叉感染也不容忽视(1.94%)。潜伏期中位数为5天。COVID-19病例密切接触者的感染率较高,应严格按照密切接触者管理方案落实隔离医学观察措施。