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活体肝移植中ABO血型不相容性胆道并发症的影像学诊断

Imaging Diagnosis of Biliary Complications of ABO Incompatibility in Living Donor Liver Transplantation.

作者信息

Wang Cheng-Kang, Cheng Yu-Fan, Chen Chao-Long, Ou Hsin-You

机构信息

Liver Transplantation Program and Departments of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Niao-Sung, Kaohsiung, Taiwan.

Liver Transplantation Program and Departments of Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Niao-Sung, Kaohsiung, Taiwan.

出版信息

Transplant Proc. 2020 Jul-Aug;52(6):1833-1837. doi: 10.1016/j.transproceed.2020.02.133. Epub 2020 May 22.

Abstract

BACKGROUND

To evaluate the imaging findings of biliary complications in patients with ABO-incompatible (ABOi) living donor liver transplantation (LDLT), with emphasis on ultrasound and magnetic resonance cholangiography results, and to evaluate clinical outcomes METHODS: The hospital's Institutional Review Committee on Human Research approved the study protocol, and all of the participants or their guardians provided written informed consent. We performed a retrospective analysis of 33 patients with ABOi LDLT from December 2009 to April 2018 enrolled in the study. After LDLT, patients were followed up daily during the admission period and every visit to the outpatient clinic following discharge. Magnetic resonance cholangiopancreatography (MRCP) was scheduled if ultrasound imaging results or clinical presentation suggested biliary complications. The types of biliary complications on MRCP were classified into nonanastomosis and anastomotic stenosis. Different interventions were arranged according to clinical conditions.

RESULTS

Of 33 patients enrolled, 4 patients were found to have abnormal ultrasound findings (12%), 10 patients had elevated liver function (30%), and 1 showed both of them (3%). Fifteen patients received MRCP in the study. Nonanastomosis strictures were found in 5 patients who received different treatment according to clinical conditions, and anastomosis strictures were found in 7 patients who received endoscopic retrograde biliary drainage treatment only. The diagnosis accuracy percentages of biliary complications by ultrasound and MRCP were 66% and 100%, respectively.

CONCLUSION

Doppler ultrasound could made a misdiagnosis in biliary complications. Magnetic resonance cholangiography is necessary if we suspect biliary complications. In addition, the differential diagnosis of biliary complications is mandatory for interventional procedures.

摘要

背景

评估ABO血型不相容(ABOi)活体肝移植(LDLT)患者胆道并发症的影像学表现,重点关注超声和磁共振胰胆管造影结果,并评估临床结局。方法:医院人体研究机构审查委员会批准了研究方案,所有参与者或其监护人提供了书面知情同意书。我们对2009年12月至2018年4月纳入研究的33例ABOi LDLT患者进行了回顾性分析。LDLT术后,患者在住院期间每日接受随访,出院后每次门诊就诊时也进行随访。如果超声成像结果或临床表现提示胆道并发症,则安排磁共振胰胆管造影(MRCP)检查。MRCP上胆道并发症的类型分为非吻合口狭窄和吻合口狭窄。根据临床情况安排不同的干预措施。结果:在纳入的33例患者中,4例超声检查结果异常(12%),10例肝功能升高(30%),1例两者均有(3%)。15例患者在研究中接受了MRCP检查。5例患者发现非吻合口狭窄,根据临床情况接受了不同治疗;7例患者发现吻合口狭窄,仅接受了内镜逆行胆道引流治疗。超声和MRCP对胆道并发症的诊断准确率分别为66%和100%。结论:多普勒超声在胆道并发症中可能会误诊。如果怀疑有胆道并发症,磁共振胰胆管造影是必要的。此外,胆道并发症的鉴别诊断对于介入治疗是必不可少的。

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