肥大细胞和嗜碱性粒细胞：从恶意设计到协同进化军备竞赛。

Mast Cells and Basophils: From Malevolent Design to Coevolutionary Arms Race.

机构信息

Laboratory of Experimental Immunology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, Sao Paulo, SP, Brazil.

Laboratory of Immunology and Bioinformatics, Department of Microbiology, Immunology and Parasitology, Institute of Biological and Natural Sciences, Federal University of Triangulo Mineiro, Uberaba, MG, Brazil.

出版信息

Trends Parasitol. 2020 Aug;36(8):655-659. doi: 10.1016/j.pt.2020.05.003. Epub 2020 May 21.

DOI:10.1016/j.pt.2020.05.003

PMID:32448702

Abstract

Mast cells and basophils are central to acquired resistance against blood-feeding arthropods which, in turn, counteract these cells by modulating their biological activities. The phenotypic exuberance displayed in this battlefield points to a reciprocal selective pressure suggesting a coevolutionary arms race that shapes both ectoparasites and vertebrate hosts.

摘要

肥大细胞和嗜碱性粒细胞是获得性抗吸血节肢动物的核心，而这些节肢动物又通过调节这些细胞的生物活性来对抗它们。在这个战场上表现出的表型过剩表明存在相互的选择压力，提示着一种共同进化的军备竞赛，这种竞赛塑造了外寄生虫和脊椎动物宿主。