Ertaş Kasım, Temiz Mustafa Zafer, Çolakerol Aykut, Küçük Suat Hayri, Şahan Ahmet, Yürük Emrah
Department of Urology, Bağcılar Training and Research Hospital, İstanbul, Turkey.
Department of Biochemistry, Bağcılar Training and Research Hospital, İstanbul, Turkey.
Turk J Urol. 2020 Mar 11;46(4):297-302. doi: 10.5152/tud.2020.19195.
To investigate the effects of flexible ureteroscopy (F-URS) on the operated side of a kidney by assessing the renal damage markers, urine neutrophil gelatinase-related lipocalin (NGAL) and serum cystatin-C (Cys-C), and overall kidney function with the measurements of standard serum creatinine and urine albumin and protein levels.
A total of 30 patients who underwent F-URS for treatment of upper urinary stone disease were prospectively evaluated. Preoperative serum urea, creatinine, and Cys-C levels were noted. Levels of urine albumin, protein, creatinine, and NGAL in spot urine samples from the operated side of a kidney obtained through the access sheath preoperatively and through the ureteral catheter 1 and 24 hours postoperatively were also measured. Preoperative and postoperative parameter levels were statistically compared.
The patients' mean age was 46.6±15.9 years. The mean operative and fluoroscopy times were 90.67±32.5 and 3.15±1.43 minutes, respectively. The urine creatinine, albumin, protein, albumin/creatinine, and protein/creatinine levels were similar in preoperative and postoperative periods. Postoperative serum urea, creatinine, and Cys-C levels and urine NGAL and NGAL/creatinine levels were not also found with remarkable changes from the baseline levels.
F-URS is a safe therapeutic intervention in the treatment of urolithiasis, especially regarding renal damage, and functional outcomes.
通过评估肾损伤标志物、尿中性粒细胞明胶酶相关脂质运载蛋白（NGAL）和血清胱抑素C（Cys-C），以及通过测量标准血清肌酐、尿白蛋白和蛋白质水平来评估总体肾功能，探讨软性输尿管镜检查（F-URS）对患侧肾脏的影响。
前瞻性评估30例因上尿路结石疾病接受F-URS治疗的患者。记录术前血清尿素、肌酐和Cys-C水平。还测量了术前通过穿刺鞘以及术后1小时和24小时通过输尿管导管从患侧肾脏采集的即时尿样中的尿白蛋白、蛋白质、肌酐和NGAL水平。对术前和术后参数水平进行统计学比较。
患者的平均年龄为46.6±15.9岁。平均手术时间和透视时间分别为90.67±32.5分钟和3.15±1.43分钟。术前和术后尿肌酐、白蛋白、蛋白质、白蛋白/肌酐和蛋白质/肌酐水平相似。术后血清尿素、肌酐和Cys-C水平以及尿NGAL和NGAL/肌酐水平与基线水平相比也未发现明显变化。
F-URS是治疗尿路结石的一种安全的治疗干预措施，尤其是在肾损伤和功能结果方面。
