Ilango Paavai, Mahendra Jaideep, Mahendra Little, Cherian Sanjay M, Kathaperumal Kumanan, Suresh Vasugi, Mahalingam Arulpari, T Abirami
Department of Periodontics, Priyadarshini Dental College and Hospital, Chennai, India.
Department of Periodontics, Meenakshi Ammal Dental College and Hospital, Chennai, India.
J Periodontol. 2021 Jan;92(1):113-122. doi: 10.1002/JPER.19-0704. Epub 2020 Jul 1.
Viruses are considered to be a newer family associated with inflammatory diseases. Yet the role of periodontal viruses in coronary artery diseases (CAD) remains unclear. Thus, the current study aims to evaluate the prevalence of periodontal viruses and compare the same in cardiac samples of CAD patients with and without periodontitis.
A total of 60 patients with CAD indicated for coronary artery bypass graft surgery (CABG) were included. These were grouped into 36 patients with healthy periodontium (CAD only) and 24 patients with periodontitis (CAD + P). The demographic variables, cardiac parameters and periodontal parameters were recorded. Cardiac tissue samples were collected during the CABG surgery and were analyzed by reverse transcriptase polymerase chain reaction for periodontal viruses such as Epstein-Barr virus (EBV), cytomegalovirus (CMV) and Herpes simplex virus. All the parameters were statistically analyzed.
Among the demographic variables, age was statistically significant between the groups. Plaque index, bleeding index, probing depth, and clinical attachment level (CAL) were significantly higher in CAD+P group (P ˂0.05). Periodontal viruses such as EBV and CMV were significantly higher (62.5% and 75% respectively, P ˂0.05) in the cardiac samples of the CAD+P than CAD only (25% and 47.2%, respectively). A significant association between EBV and CAL was revealed by multiple logistic regression analysis. (B = 0.374, P = 0.046) CONCLUSIONS: The results revealed a higher prevalence of periodontal viruses such as EBV and CMV in CAD patients with periodontitis suggesting it as one of the risk factors for CAD. This is supported by the fact that severity of periodontal disease (CAL) is associated with the presence of EBV in coronary artery plaque samples in the current study.
病毒被认为是与炎症性疾病相关的一个新家族。然而，牙周病毒在冠状动脉疾病（CAD）中的作用仍不清楚。因此，本研究旨在评估牙周病毒的患病率，并比较患有和未患有牙周炎的CAD患者心脏样本中的牙周病毒情况。
总共纳入了60例因冠状动脉旁路移植术（CABG）而接受手术的CAD患者。这些患者被分为36例牙周健康的患者（仅CAD）和24例患有牙周炎的患者（CAD + P）。记录人口统计学变量、心脏参数和牙周参数。在CABG手术期间收集心脏组织样本，并通过逆转录聚合酶链反应分析牙周病毒，如爱泼斯坦 - 巴尔病毒（EBV）、巨细胞病毒（CMV）和单纯疱疹病毒。对所有参数进行统计学分析。
在人口统计学变量中，两组之间年龄具有统计学意义。CAD + P组的菌斑指数、出血指数、探诊深度和临床附着水平（CAL）显著更高（P ˂0.05）。CAD + P组心脏样本中的EBV和CMV等牙周病毒显著高于仅CAD组（分别为62.5%和75%，P ˂0.05），而仅CAD组分别为25%和47.2%。多因素逻辑回归分析显示EBV与CAL之间存在显著关联。（B = 0.374，P = 0.046）结论：结果显示，患有牙周炎的CAD患者中EBV和CMV等牙周病毒的患病率较高，表明其为CAD的危险因素之一。本研究中牙周疾病的严重程度（CAL）与冠状动脉斑块样本中EBV的存在相关，这一事实支持了上述结论。
