Department of Neuroscience, Imaging and Clinical Science, and Aging Research Centre, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.
Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Neurobiol Aging. 2020 Sep;93:55-60. doi: 10.1016/j.neurobiolaging.2020.04.023. Epub 2020 Apr 29.
Electroencephalography (EEG) slowing with prealpha dominant frequency (DF) in posterior derivations is a biomarker for dementia with Lewy bodies (DLB) diagnosis, in contrast with Alzheimer's disease (AD). However, an intrasubject re-evaluation of the original data, which contributed to the identification of EEG DLB biomarker, showed that DF was slower in anterior than posterior derivations. We suppose this anterior-posterior gradient of DF slowing could arise in DLB from a thalamocortical dysrhythmia, differently involving the anterior and posterior cortical areas, and correlating with cognitive impairment (Mini-Mental State Examination). EEG was recorded in 144 DLB, 116 AD, and 65 controls from 7 Centers of the European DLB Consortium. Spectra were divided into delta, theta, prealpha, alpha frequency bands. In DLB, mean DF was prealpha both anteriorly and posteriorly, but lower anteriorly (p < 0.001). In 14% of DLB, DF was prealpha anteriorly, whereas alpha posteriorly. In AD and controls, DF was constantly alpha. EEG slowing in DLB correlated with cognitive impairment. Thalamocortical dysrhythmia gives rise to prealpha rhythm with an anterior-posterior gradient and correlates with impaired cognition.
脑电图（EEG）慢波 alpha 频带（DF）在后部导联出现，是路易体痴呆（DLB）的诊断生物标志物，与阿尔茨海默病（AD）相反。然而，对有助于确定 EEG DLB 生物标志物的原始数据进行的个体内重新评估表明，DF 在额部导联比在后部导联更慢。我们推测，这种 DF 减慢的前后梯度可能源于皮质丘脑节律紊乱，不同程度地涉及额部和后部皮质区域，并与认知障碍（迷你精神状态检查）相关。脑电图记录来自欧洲 DLB 联盟的 7 个中心的 144 例 DLB、116 例 AD 和 65 例对照。频谱分为 delta、theta、prealpha 和 alpha 频带。在 DLB 中，前、后导联的平均 DF 均为 prealpha，但前导联的 DF 较低（p<0.001）。在 14%的 DLB 中，DF 在前部为 prealpha，而在后部为 alpha。在 AD 和对照组中，DF 始终为 alpha。DLB 的 EEG 减慢与认知障碍相关。皮质丘脑节律紊乱产生具有前后梯度的 prealpha 节律，并与认知障碍相关。
