Simonenkova V A, Bondarenko I G
Tsitologiia. 1988 Nov;30(11):1383-5.
A histochemical method is described for localizing xanthine oxidase--the key enzyme in the purine catabolic pathway. The above method is based on the reduction of p-Nitroblue tetrazolium during hypoxanthine enzymatic oxidation, phenazine methosulfate being an intermediate electron acceptor. The patterns of the reaction product distribution suggest that the Kupffer cells and the sinusoidal endothelium possess the highest xanthine oxidase activity.
本文描述了一种用于定位黄嘌呤氧化酶（嘌呤分解代谢途径中的关键酶）的组织化学方法。上述方法基于次黄嘌呤酶促氧化过程中对硝基蓝四唑的还原，硫酸吩嗪作为中间电子受体。反应产物分布模式表明，库普弗细胞和窦状内皮细胞具有最高的黄嘌呤氧化酶活性。
