实验性肾盂肾炎中尿乳酸脱氢酶同工酶5的排泄
Urinary LDH isoenzyme 5 excretion in experimental pyelonephritis.
作者信息
Cunningham R J, Carvajal H F, Passey R B
出版信息
Br J Exp Pathol. 1977 Apr;58(2):220-4.
Studies to determine the effect of kidney parenchymal infection upon urinary lactic dehydrogenase (ULDH) isoenzyme composition were performed in 12 female Sprague-Dawley rats on Day 0 and on Days 2, 5, and 10, after experimental inducement of Escherichia coli pyelonephritis. An additional group of 12 animals was subjected to similar experimental manipulations and served as sham controls. Repeated 12-h urine collections revealed lower urine osmolalities and significantly higher levels of ULDH 5 excretion in the experimental than in the sham operated animals (P less than 0-05). These differences persisted for the length of the experiment (10 days). Leucocyte excretion rates were also higher in the experimental than in the sham group, and a high correlation with ULDH 5 activity was demonstrated (r = 0-815). No other evidence that the two variables may be causally related was found.
为确定肾实质感染对尿乳酸脱氢酶（ULDH）同工酶组成的影响，在第0天以及实验性诱发大肠杆菌肾盂肾炎后的第2、5和10天，对12只雌性斯普拉格 - 道利大鼠进行了研究。另外一组12只动物接受了类似的实验操作，并作为假手术对照。重复进行12小时尿液收集发现，与假手术动物相比，实验动物的尿渗透压较低，且ULDH 5排泄水平显著更高（P小于0.05）。这些差异在实验的10天期间一直存在。实验动物的白细胞排泄率也高于假手术组，并且与ULDH 5活性显示出高度相关性（r = 0.815）。未发现其他证据表明这两个变量可能存在因果关系。
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