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HIV 如何在子宫内膜中利用 T 细胞。

How HIV exploits T cells in the endometrium.

机构信息

Department of Immunology, Tufts University School of Medicine, Boston, United States.

出版信息

Elife. 2020 May 26;9:e58169. doi: 10.7554/eLife.58169.

DOI:10.7554/eLife.58169
PMID:32452383
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7250570/
Abstract

Immune cells in the endometrium are targeted by HIV and re-programmed to allow them to survive and spread the virus throughout the body.

摘要

子宫内膜中的免疫细胞成为 HIV 的攻击目标,并被重新编程,使它们能够存活并将病毒传播到全身。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effb/7250570/4bbaf4cff14c/elife-58169-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effb/7250570/4bbaf4cff14c/elife-58169-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effb/7250570/4bbaf4cff14c/elife-58169-fig1.jpg

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本文引用的文献

1
HIV efficiently infects T cells from the endometrium and remodels them to promote systemic viral spread.HIV 能够有效地感染子宫内膜中的 T 细胞,并对其进行重塑,从而促进病毒在全身范围内的传播。
Elife. 2020 May 26;9:e55487. doi: 10.7554/eLife.55487.
2
Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa.宫颈黏膜中的固有记忆 T 细胞是 HIV 的细胞储库。
Nat Commun. 2019 Oct 18;10(1):4739. doi: 10.1038/s41467-019-12732-2.
3
Effects of the levonorgestrel-containing intrauterine device, copper intrauterine device, and levonorgestrel-containing oral contraceptive on susceptibility of immune cells from cervix, endometrium and blood to HIV-1 fusion measured ex vivo.
左炔诺孕酮宫内节育器、含铜宫内节育器和左炔诺孕酮口服避孕药对离体测量宫颈、子宫内膜和血液免疫细胞对 HIV-1 融合的敏感性的影响。
PLoS One. 2019 Aug 22;14(8):e0221181. doi: 10.1371/journal.pone.0221181. eCollection 2019.
4
BIOMEDICAL PREVENTION OF HIV IN WOMEN: CHALLENGES AND APPROACHES, WITH PARTICULAR REFERENCE TO THE VAGINAL MICROBIOME.女性HIV的生物医学预防:挑战与方法,特别涉及阴道微生物群
Trans Am Clin Climatol Assoc. 2018;129:63-73.
5
Th17 Cells Are Preferentially Infected Very Early after Vaginal Transmission of SIV in Macaques.在猕猴中,SIV经阴道传播后,Th17细胞在极早期就优先受到感染。
Cell Host Microbe. 2016 Apr 13;19(4):529-40. doi: 10.1016/j.chom.2016.03.005.
6
Identification of preferential CD4+ T-cell targets for HIV infection in the cervix.确定子宫颈中HIV感染的优先CD4+ T细胞靶点。
Mucosal Immunol. 2016 Jan;9(1):1-12. doi: 10.1038/mi.2015.28. Epub 2015 Apr 15.
7
The role of sex hormones in immune protection of the female reproductive tract.性激素在女性生殖道免疫保护中的作用。
Nat Rev Immunol. 2015 Apr;15(4):217-30. doi: 10.1038/nri3819. Epub 2015 Mar 6.
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Vaginal challenge with an SIV-based dual reporter system reveals that infection can occur throughout the upper and lower female reproductive tract.使用基于猴免疫缺陷病毒(SIV)的双报告系统进行阴道激发试验,结果显示感染可发生在女性上、下生殖道的整个区域。
PLoS Pathog. 2014 Oct 9;10(10):e1004440. doi: 10.1371/journal.ppat.1004440. eCollection 2014 Oct.
9
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Mucosal Immunol. 2014 Nov;7(6):1375-85. doi: 10.1038/mi.2014.26. Epub 2014 Apr 23.
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