Zhang Jinsong, Qiu Meihui, Pan Jingxue, Zhao Lun
Department of Medical Psychology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine and Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Shanghai.
School of Educational Science, Liaocheng University, Liaocheng, China.
Neuroreport. 2020 Jul 10;31(10):776-779. doi: 10.1097/WNR.0000000000001472.
To investigate the preattentive change detection in preschool children with attention deficit hyperactivity disorder (ADHD), we compared the mismatch negativity (MMN) and P3a of event-related potentials (ERPs) between preschool ADHD and normal children using three-stimulus oddball paradigm. Analyzing MMN and P3a components, we found that MMN elicited by deviants and P3a elicited by novelty were significantly reduced in patients than in controls. In addition, the P3a amplitude was positive correlated to IQ and negatively correlated to hyperactivity, antagonistic defiance and conduct problems in Swanson, Nolan, and Pelham IV Rating Scale, parent version. These data provided new neurophysiological evidence for the dysfunction of preattentive change detection and attentional shift in ADHD children.
为了研究注意力缺陷多动障碍（ADHD）学龄前儿童的前注意变化检测，我们使用三刺激偏差范式比较了学龄前ADHD儿童和正常儿童事件相关电位（ERP）的失匹配负波（MMN）和P3a。通过分析MMN和P3a成分，我们发现与对照组相比，患者中由偏差刺激诱发的MMN和由新异刺激诱发的P3a显著降低。此外，在斯旺森、诺兰和佩勒姆第四版评定量表家长版中，P3a波幅与智商呈正相关，与多动、对立违抗和品行问题呈负相关。这些数据为ADHD儿童前注意变化检测和注意转移功能障碍提供了新的神经生理学证据。
