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[胆碱能机制在犬实验性神经症记忆过程中的作用]

[The role of cholinergic mechanisms in memory processes in experimental neurosis in dogs].

作者信息

Doronin A G, Taldykin P E, Mantulo P M

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1988 Nov-Dec;38(6):1138-44.

PMID:3245324
Abstract

In experiments on dogs the role was studied of cholinergic mechanisms in memory processes at different stages of neurosis. Predominance was shown in initial state of M-cholinergic mechanisms which also in conditions of neurotic inhibition of conditioned activity decrease the level of functioning less than N-cholinergic link. In the postneurotic period excessive activity of N-cholinergic memory mechanism was revealed. The supposed mechanisms are discussed of cholinergic system disturbances in neurosis dynamics and possibility of their pharmacological correction.

摘要

在对狗的实验中,研究了胆碱能机制在神经症不同阶段记忆过程中的作用。结果表明,在神经症初始状态时,M胆碱能机制占主导地位,而且在条件活动的神经症性抑制情况下,其功能水平的降低程度小于N胆碱能环节。在神经症后阶段,发现N胆碱能记忆机制活动过度。文中讨论了神经症动态过程中胆碱能系统紊乱的假定机制及其药理纠正的可能性。

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