Xie Qiao-Mei, Lou Qiu-Yue, Huang Shun-Wei, Hu Hua-Qing, Li Su-Su, Zhang Man, Sun Xiu-Xiu, Xu Jian-Hua, Jiang Shan-Qun, Liu Sheng-Xiu, Xu Sheng-Qian, Cai Jing, Liu Shuang, Pan Fa-Ming, Tao Jin-Hui, Qian Long, Wang Chun-Huai, Liang Chun-Mei, Huang Hai-Liang, Pan Hai-Feng, Su Hong, Zou Yan-Feng
From the Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University.
The Key Laboratory of Anhui Medical Autoimmune Diseases.
J Clin Rheumatol. 2020 Jun;26(4):134-141. doi: 10.1097/RHU.0000000000000986.
The aim of this study is to investigate whether heat shock protein 70 (Hsp70) gene polymorphisms are implicated in systemic lupus erythematous (SLE) susceptibility, the efficacy of glucocorticoids (GCs) treatment, and improvement of health-related quality of life.
A total of 499 SLE patients and 499 controls were included in a case-control study, and 468 SLE patients treated with GCs for 12 weeks were involved in a follow-up study. Patients who completed the 12-week follow-up were divided into GCs-sensitive and GCs-insensitive group by using the SLE disease activity index. The SF-36 was used to evaluate the health-related quality of life of SLE patients, and genotyping was performed by improved multiplex ligation detection reaction.
rs2075800 was associated with SLE susceptibility (adjusted odds ratio [ORadj], 1.437; 95% confidence interval [CI], 1.113-1.855; Padj = 0.005; PBH = 0.020 by dominant model; ORadj, 1.602; 95% CI, 1.072-2.395; Padj = 0.022; PBH = 0.029 by TT vs CC model; ORadj = 1.396; 95% CI = 1.067-1.826; Padj = 0.015; PBH = 0.029 by TC vs CC model). In the follow-up study, rs2075799 was associated with the improvement in mental health (p = 0.004, PBH = 0.044), but we failed to find any association between the efficacy of GCs and Hsp70 gene polymorphisms.
Hsp70 gene polymorphisms may be associated with susceptibility to SLE and improvement of mental health in Chinese Han population.
本研究旨在探讨热休克蛋白70（Hsp70）基因多态性是否与系统性红斑狼疮（SLE）易感性、糖皮质激素（GCs）治疗疗效及健康相关生活质量改善有关。
一项病例对照研究纳入了499例SLE患者和499例对照，一项随访研究纳入了468例接受GCs治疗12周的SLE患者。完成12周随访的患者根据SLE疾病活动指数分为GCs敏感组和GCs不敏感组。采用SF-36评估SLE患者的健康相关生活质量，通过改进的多重连接检测反应进行基因分型。
rs2075800与SLE易感性相关（显性模型下调整比值比[ORadj]为1.437；95%置信区间[CI]为1.113 - 1.855；Padj = 0.005；PBH = 0.020；TT与CC模型下ORadj为1.602；95% CI为1.072 - 2.395；Padj = 0.022；PBH = 0.029；TC与CC模型下ORadj = 1.396；95% CI = 1.067 - 1.826；Padj = 0.015；PBH = 0.029）。在随访研究中，rs2075799与心理健康改善相关（p = 0.004，PBH = 0.044），但我们未发现GCs疗效与Hsp70基因多态性之间存在任何关联。
Hsp70基因多态性可能与中国汉族人群的SLE易感性及心理健康改善有关。
