Kankaanpää Anna, Harju Teemu, Numminen Jura
Department of Otorhinolaryngology, Tampere University Hospital, Tampere, Finland.
Ear Nose Throat J. 2021 Dec;100(10_suppl):1107S-1112S. doi: 10.1177/0145561320927944. Epub 2020 May 26.
The purpose of this prospective, randomized, single-blinded, placebo-controlled study was to investigate the effects of radiofrequency ablation (RFA), diode laser, and microdebrider-assisted inferior turbinoplasty (MAIT) techniques on patients' quality of life (QOL) and to compare the techniques with a placebo procedure.
A total of 98 consecutive patients with enlarged inferior turbinates due to persistent year-round rhinitis were randomized into placebo, RFA, diode laser, and MAIT groups at a ratio of 1:2:2:2. All the procedures were carried out under local anesthesia with the patients' eyes covered. Assessments were conducted prior to surgery and 3 months subsequent to the surgery. Quality of life was assessed with the Glasgow Health Status Inventory (GHSI).
The GHSI total score increased statistically significantly in all the groups, including placebo. There were no significant differences in the GHSI total score change between RFA, diode laser, and MAIT groups. The MAIT procedure improved the GHSI total score significantly more than the placebo procedure ( = .04).
All inferior turbinate surgery techniques lead to a significant improvement in the patients' QOL, and no significant differences were found between the techniques. The placebo treatment also improved the QOL significantly. Only the MAIT technique improved the QOL significantly more compared to placebo.
本前瞻性、随机、单盲、安慰剂对照研究旨在探讨射频消融术（RFA）、二极管激光和微型切割器辅助下鼻甲成形术（MAIT）技术对患者生活质量（QOL）的影响，并将这些技术与安慰剂手术进行比较。
总共98例因常年性持续性鼻炎导致下鼻甲肿大的连续患者，按照1:2:2:2的比例随机分为安慰剂组、RFA组、二极管激光组和MAIT组。所有手术均在局部麻醉下进行，患者眼睛被遮盖。在手术前和手术后3个月进行评估。使用格拉斯哥健康状况量表（GHSI）评估生活质量。
包括安慰剂组在内的所有组中，GHSI总分均有统计学意义的显著增加。RFA组、二极管激光组和MAIT组之间的GHSI总分变化无显著差异。MAIT手术使GHSI总分的改善显著大于安慰剂手术（P = .04）。
所有下鼻甲手术技术均能显著改善患者的生活质量，且各技术之间未发现显著差异。安慰剂治疗也显著改善了生活质量。与安慰剂相比，只有MAIT技术能更显著地改善生活质量。
