Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
J Am Acad Dermatol. 2020 Dec;83(6):1559-1565. doi: 10.1016/j.jaad.2020.04.183. Epub 2020 May 23.
Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by intensely pruritic, hyperkeratotic nodules that favor the extensor surfaces of the extremities and the trunk. In addition to its significant impact on quality of life, many patients with PN are recalcitrant to therapy because there are currently no therapies approved by the US Food and Drug Administration. In the first article of this 2-part continuing medical education series, we describe the broader epidemiology, patient demographics, physical examination findings, and symptoms to aid in the timely recognition and diagnosis of PN. Furthermore, we quantify the burden of comorbidities in PN by discussing the broad spectrum of systemic diseases and mental health conditions that have been associated with this condition. The second article of this 2-part series focuses on the pathogenesis of PN and provides detailed algorithms for comprehensive work-up and management.
结节性痒疹（PN）是一种慢性炎症性皮肤病，其特征为剧烈瘙痒、角化过度的结节，多见于四肢和躯干的伸展面。除了对生活质量有重大影响外，许多 PN 患者对治疗有抵触，因为目前还没有获得美国食品和药物管理局批准的疗法。在这个两部分继续医学教育系列的第一篇文章中，我们描述了更广泛的流行病学、患者人口统计学、体格检查结果和症状，以帮助及时识别和诊断 PN。此外，我们通过讨论与这种疾病相关的广泛的系统性疾病和心理健康状况，量化了 PN 合并症的负担。本系列的第二篇文章重点介绍了 PN 的发病机制，并提供了详细的综合检查和管理算法。
