Donaldson David S, Pollock Jolinda, Vohra Prerna, Stevens Mark P, Mabbott Neil A
The Roslin Institute & Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Easter Bush EH25 9RG, UK.
The Roslin Institute & Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Easter Bush EH25 9RG, UK.
iScience. 2020 Jun 26;23(6):101147. doi: 10.1016/j.isci.2020.101147. Epub 2020 May 11.
Aging has a profound effect on the immune system, termed immunosenescence, resulting in increased incidence and severity of infections and decreased efficacy of vaccinations. We previously showed that immunosurveillance in the intestine, achieved primarily through antigen sampling M cells in the follicle associated epithelium (FAE) of Peyer's patches, was compromised during aging due to a decline in M cell functional maturation. The intestinal microbiota also changes significantly with age, but whether this affects M cell maturation was not known. We show that housing of aged mice on used bedding from young mice, or treatment with bacterial flagellin, were each sufficient to enhance the functional maturation of M cells in Peyer's patches. An understanding of the mechanisms underlying the influence of the intestinal microbiota on M cells has the potential to lead to new methods to enhance the efficacy of oral vaccination in aged individuals.
衰老对免疫系统有深远影响，即免疫衰老，导致感染的发生率和严重程度增加，疫苗接种效果降低。我们之前表明，肠道中的免疫监视主要通过派尔集合淋巴结滤泡相关上皮（FAE）中的抗原采样M细胞来实现，在衰老过程中，由于M细胞功能成熟度下降，免疫监视受到损害。肠道微生物群也会随着年龄的增长而发生显著变化，但这是否会影响M细胞成熟尚不清楚。我们发现，将老年小鼠饲养在年轻小鼠使用过的垫料上，或用细菌鞭毛蛋白进行处理，都足以增强派尔集合淋巴结中M细胞的功能成熟。了解肠道微生物群对M细胞影响的潜在机制，有可能带来提高老年个体口服疫苗接种效果的新方法。
